Frenia 2 mg Tablet contains Frenia (active ingredient: 2 mg), an atypical neuroleptic drug designed for the treatment of schizophrenia, other psychotic disorders, and mania associated with bipolar disorder. It is particularly effective in managing both positive symptoms (such as hallucinations, delusions, thought disturbances, hostility, and suspiciousness) and negative symptoms (including emotional withdrawal, blunted affect, and poverty of speech). Frenia 2 mg also alleviates affective symptoms like depression, guilt feelings, and anxiety associated with schizophrenia and maintains clinical improvement during continuation therapy in responsive patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Frenia 2 mg Tablet is indicated for:

• Acute and chronic schizophrenic psychoses

• Other psychotic conditions with prominent positive or negative symptoms

• Affective symptoms associated with schizophrenia, including depression and anxiety

• Maintenance therapy in patients who have responded to initial treatment

• Treatment of mania in bipolar disorder

Therapeutic Class

Atypical Neuroleptic / Second-Generation Antipsychotic

Pharmacology

Frenia 2 mg is a selective monoaminergic antagonist with high affinity for serotonin 5-HT2 and dopamine D2 receptors. It also binds to alpha1-adrenergic receptors and, to a lesser extent, H1 histamine and alpha2-adrenergic receptors, while having negligible affinity for cholinergic receptors. Its balanced antagonism of dopamine and serotonin helps reduce positive symptoms of schizophrenia while minimizing motor side effects and extending therapeutic effects to negative and affective symptoms.

Dosage and Administration

Psychoses:

• Day 1: 2 mg in 1–2 divided doses

• Day 2: 4 mg in 1–2 divided doses

• Usual range: 4–6 mg daily; doses above 10 mg only if benefits outweigh risks

• Maximum: 16 mg daily

Mania:

• Initial: 2 mg once daily, increased by 1 mg increments as needed

• Usual range: 1–6 mg daily

Elderly or patients with hepatic/renal impairment:

• Start with 1 mg daily in two divided doses, increasing by 1–2 mg increments

Children under 15 years: Not recommended

Schizophrenia:

• Initial: 1 mg twice daily, increased by 1 mg increments every 1–3 days to a target of 3 mg twice daily

• Further adjustments at intervals of no less than 1 week

Drug Interactions

• May antagonize levodopa and other dopamine agonists

• Chronic use with carbamazepine reduces plasma clearance

• Chronic use with clozapine may decrease clearance

• May enhance effects of certain antihypertensives

Contraindications

• Known hypersensitivity to Frenia 2 mg or any formulation component

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects include:

• Insomnia, agitation, anxiety, headache

• Drowsiness, impaired concentration, fatigue

• Gastrointestinal: nausea, vomiting, dyspepsia, abdominal pain, constipation

• Cardiovascular: tachycardia, hypertension, edema

• Urinary incontinence, blurred vision

• Endocrine: hyperprolactinemia

• Rare: cerebrovascular events, neutropenia, thrombocytopenia, rash, rhinitis

Pregnancy and Lactation

• Pregnancy: No teratogenic effects observed in animal studies; human safety not established

• Lactation: Excreted in breast milk; breastfeeding is not recommended during therapy

Precautions and Warnings

• Caution in patients with cardiovascular disease, epilepsy, Parkinson’s disease, or renal/hepatic impairment

• Discontinue if signs of tardive dyskinesia occur

• Use caution in elderly and pregnant patients

Overdose Effects

• Drowsiness, sedation, tachycardia, hypotension, extrapyramidal symptoms

• Severe cases may require anticholinergic medication and close medical supervision

• No specific antidote available

Storage Conditions

• Store in a cool, dry place, protected from light