Betabis Plus Tablet 5 mg+6.25 mg is a fixed-dose antihypertensive combination containing Bisoprolol Fumarate and Hydrochlorothiazide. This formulation is designed for patients who require enhanced and sustained blood pressure control when single-agent therapy is insufficient. By combining a cardio-selective beta-blocker with a thiazide diuretic, Betabis Plus provides complementary mechanisms to effectively manage hypertension and reduce cardiovascular risk.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Bisoprolol Fumarate 5 mg

• Hydrochlorothiazide 6.25 mg

Therapeutic Class

• Selective beta-1 adrenergic blocker

• Thiazide diuretic

• Antihypertensive combination

Pharmacology

Bisoprolol Fumarate selectively blocks beta-1 adrenergic receptors in the heart, reducing the effects of catecholamines such as adrenaline. This leads to a decrease in heart rate, myocardial contractility, and cardiac output, thereby lowering blood pressure and reducing cardiac workload.

Hydrochlorothiazide acts on the distal renal tubules to promote the excretion of sodium and water. This diuretic effect decreases plasma volume and peripheral vascular resistance, contributing to effective blood pressure reduction.

The combination of these two agents offers additive antihypertensive effects. Bisoprolol controls heart rate and cardiac output, while hydrochlorothiazide enhances fluid and sodium elimination, resulting in stable and long-lasting blood pressure control.

Indications

Betabis Plus Tablet 5 mg+6.25 mg is indicated for:

• Treatment of essential hypertension

• Patients requiring combination therapy for optimal blood pressure control

• Individuals inadequately controlled with monotherapy

Dosage and Administration

• The usual dose is one tablet once daily, preferably taken in the morning.

• The tablet should be swallowed whole with sufficient water.

• It may be taken with or without food.

• Dose adjustments should be made only under medical supervision.

• Abrupt discontinuation should be avoided.

Precautions and Warnings

• Use with caution in patients with renal or hepatic impairment.

• Regular monitoring is advised in patients with diabetes, gout, or electrolyte imbalance.

• Bisoprolol may mask signs of hypoglycemia, and hydrochlorothiazide may affect glucose and electrolyte levels.

• Caution is advised during pregnancy and breastfeeding unless clearly indicated.

• Periodic monitoring of blood pressure, renal function, and electrolytes is recommended during long-term therapy.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Some patients may experience:

• Dizziness or fatigue

• Slow heart rate

• Increased urination

• Electrolyte disturbances

• Headache or gastrointestinal discomfort

Most side effects are mild and transient. If severe symptoms such as fainting, severe weakness, or dehydration occur, medical attention should be sought immediately.

Storage

• Store in a cool, dry place below 30°C.

• Protect from light and moisture.

• Keep out of reach of children.

Conclusion

Betabis Plus Tablet 5 mg+6.25 mg offers a reliable and effective combination approach for managing hypertension. By uniting the cardio-selective action of bisoprolol with the diuretic benefits of hydrochlorothiazide, it ensures improved blood pressure control and enhanced cardiovascular protection when used under appropriate medical supervision.