Bipinor Plus Tablet is a combination antihypertensive medication containing Nebivolol (5 mg) and Hydrochlorothiazide (12.5 mg). This dual-action therapy is designed to effectively control high blood pressure by combining a cardioselective beta-blocker with a thiazide diuretic.

Nebivolol reduces heart rate and relaxes blood vessels, while Hydrochlorothiazide helps remove excess fluid and sodium from the body. Together, they provide enhanced blood pressure control compared to monotherapy, reducing the risk of cardiovascular complications such as stroke, heart attack, and kidney damage.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Bipinor Plus Tablet is indicated for:

• Management of essential hypertension
• Patients requiring combination therapy for better blood pressure control
• Reduction of cardiovascular risk associated with uncontrolled hypertension
• Patients not adequately controlled with a single antihypertensive agent

Composition

• Active Ingredients:
  • Nebivolol – 5 mg
  • Hydrochlorothiazide – 12.5 mg
• Dosage Form: Oral tablet

Mechanism of Action

Bipinor Plus Tablet works through complementary mechanisms:

• Nebivolol: A selective beta-1 adrenergic blocker that reduces heart rate and cardiac output while promoting nitric oxide-mediated vasodilation, improving blood flow
• Hydrochlorothiazide: A thiazide diuretic that increases the excretion of sodium and water through urine, reducing blood volume and lowering blood pressure

This combination provides effective and sustained control of hypertension through both vascular relaxation and fluid reduction.

Dosage & Administration

• Adults: সাধারণত 1 tablet once daily or as prescribed by a physician
• Take with or without food
• Swallow with a full glass of water
• Regular monitoring of blood pressure, electrolytes, and kidney function is recommended
• Do not discontinue abruptly without medical advice

Side Effects

Bipinor Plus Tablet is generally well tolerated. Possible side effects include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Increased urination (especially at the start of therapy)
• Electrolyte imbalance (low potassium, sodium)
• Nausea or mild gastrointestinal discomfort
• Rare: bradycardia, hypotension, or allergic reactions

Consult a physician if symptoms persist or worsen.

Precautions & Warnings

• Use cautiously in patients with renal impairment, liver disease, or diabetes
• Monitor electrolyte levels regularly, especially potassium and sodium
• Avoid use in patients with severe bradycardia or heart block
• Increased sensitivity may occur in elderly patients
• Avoid dehydration; maintain adequate fluid intake

Drug Interactions

• May interact with other antihypertensives, increasing the risk of hypotension
• NSAIDs may reduce the antihypertensive effect
• Concomitant use with lithium, digoxin, or corticosteroids requires caution
• Potassium-altering drugs may increase the risk of electrolyte imbalance

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Not recommended unless clearly necessary
• Lactation: Use with caution; consult a physician
• Elderly: Dose adjustment and close monitoring may be required

Storage

• Store below 25°C in a cool and dry place
• Protect from light and moisture
• Keep out of reach of children.