Caloplax Tablet 2 mg contains Prucalopride Succinate, a selective serotonin 5-HT4 receptor agonist designed for the treatment of chronic idiopathic constipation (CIC) in adults. This higher-strength formulation is particularly suited for patients who do not achieve adequate symptom relief with the standard 1 mg dose. By enhancing colonic motility and promoting regular bowel movements, Caloplax Tablet 2 mg provides effective relief from constipation-related discomfort and improves overall quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Prucalopride Succinate 2 mg

Therapeutic Class

• Gastrointestinal prokinetic agent

• Selective 5-HT4 receptor agonist

• Treatment of chronic idiopathic constipation

Pharmacology and Mechanism of Action

Prucalopride, the active ingredient in Caloplax, selectively stimulates 5-HT4 receptors in the gastrointestinal tract. Activation of these receptors enhances peristalsis, accelerates colonic transit, and facilitates the passage of stool.

Unlike conventional laxatives, which rely on osmotic effects or stool softening, prucalopride addresses the underlying motility dysfunction in chronic constipation. It acts primarily in the colon, restoring physiological bowel function while minimizing systemic side effects.

This targeted mechanism helps alleviate associated symptoms such as straining, bloating, and abdominal discomfort, while improving bowel movement frequency and consistency.

Indications

Caloplax Tablet 2 mg is indicated for:

• Chronic idiopathic constipation (CIC) in adults

• Patients with inadequate response to lower doses of prucalopride or conventional laxatives

• Improvement of bowel movement frequency, stool consistency, and overall gastrointestinal comfort

Dosage and Administration

Caloplax Tablet 2 mg is taken orally, usually once daily with or without food. Tablets should be swallowed whole with water.

• Standard starting dose is typically 1 mg; 2 mg may be prescribed for patients requiring higher efficacy.

• Dose adjustments may be necessary in patients with severe renal or hepatic impairment.

• The duration of therapy is determined by the treating physician based on symptom improvement and tolerability.

Treatment should not be stopped abruptly without consulting a healthcare professional.

Benefits

• Provides effective relief from chronic constipation resistant to standard therapy

• Restores regular bowel movements and improves stool consistency

• Reduces straining, bloating, and abdominal discomfort

• Works through a physiological mechanism to improve colonic motility

• Suitable for long-term use under medical supervision

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not recommended for patients with mechanical gastrointestinal obstruction, severe inflammatory bowel disease, or hypersensitivity to prucalopride

• Use with caution in patients with significant renal or hepatic impairment

• May cause mild gastrointestinal side effects such as diarrhea, nausea, or abdominal pain initially

• Discontinue and consult a physician if severe or persistent side effects occur

• Use during pregnancy and breastfeeding only if clearly advised by a healthcare professional

Storage

Store below 30°C in a dry, cool place. Protect from light and moisture. Keep out of reach of children.