Calvasc Tablet 5 mg contains Amlodipine Besilate, a long-acting calcium channel blocker used primarily for the management of hypertension and angina pectoris. Amlodipine belongs to the dihydropyridine class of calcium channel blockers, which work by relaxing blood vessels and improving blood flow, reducing both blood pressure and cardiac workload.

Calvasc 5 mg is indicated for patients with essential hypertension, chronic stable angina, or vasospastic (Prinzmetal’s) angina, providing once-daily dosing for convenient and sustained therapeutic effects. By targeting the vascular smooth muscle, it helps prevent complications associated with high blood pressure such as stroke, myocardial infarction, and heart failure.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Amlodipine Besilate 5 mg

Mechanism of Action

Amlodipine works by inhibiting calcium ion influx through L-type calcium channels in vascular smooth muscle and cardiac muscle:

• Vascular Effects: Causes vasodilation, reducing peripheral resistance and blood pressure

• Cardiac Effects: Decreases myocardial oxygen demand, helping relieve angina symptoms

• Coronary Effects: Improves coronary blood flow, reducing ischemic episodes

Its slow onset and long duration of action provide stable blood pressure control and reduce the frequency of angina attacks with minimal fluctuations in drug levels.

Indications

Calvasc Tablet 5 mg is indicated for:

• Essential hypertension – to lower elevated blood pressure and reduce cardiovascular risk

• Chronic stable angina – to prevent angina attacks and improve exercise tolerance

• Vasospastic (Prinzmetal’s) angina – to relieve chest pain caused by coronary artery spasm

• Hypertensive patients at risk of cardiovascular complications

Benefits

• Effective Blood Pressure Control: Lowers systolic and diastolic blood pressure efficiently

• Relieves Angina Symptoms: Reduces frequency and severity of chest pain

• Improves Coronary Circulation: Enhances oxygen delivery to heart muscles

• Once-Daily Dosing: Ensures compliance and sustained effect throughout the day

• Well-Tolerated: Minimal central nervous system side effects, suitable for long-term therapy

• Prevents Cardiovascular Complications: Reduces the risk of heart attack, stroke, and heart failure in hypertensive patients

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Adults: 1 tablet (5 mg) orally once daily, preferably at the same time each day

• Can be taken with or without food

• Dose may be increased gradually to 10 mg daily based on blood pressure response and tolerance

• Elderly patients may require careful dose adjustment

• Regular monitoring of blood pressure and heart rate is recommended

Safety and Precautions

• Common side effects: headache, dizziness, flushing, peripheral edema (ankle swelling), and fatigue

• Rare side effects: palpitations, hypotension, or liver enzyme changes

• Contraindicated in patients with severe hypotension, cardiogenic shock, or known hypersensitivity to Amlodipine

• Use with caution in patients with severe aortic stenosis, heart failure, or liver impairment

• Pregnant or breastfeeding women should use only under medical supervision

• Avoid abrupt discontinuation to prevent rebound hypertension or angina exacerbation.