Cardiver Tablet 2.5 mg is a cardiovascular medication containing Vericiguat, a novel oral soluble guanylate cyclase (sGC) stimulator. It is primarily indicated for the management of chronic heart failure with reduced ejection fraction (HFrEF) in adult patients who have recently experienced worsening heart failure events. Cardiver Tablet is used as part of a comprehensive heart failure treatment regimen to reduce the risk of hospitalization and cardiovascular complications.

Vericiguat represents an advanced therapeutic approach in heart failure management by directly targeting impaired nitric oxide signaling, a key pathophysiological mechanism involved in disease progression.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Vericiguat 2.5 mg

• Dosage Form: Tablet

• Pharmacological Class: Soluble Guanylate Cyclase (sGC) Stimulator

Mechanism of Action

In heart failure, reduced nitric oxide availability leads to impaired activation of soluble guanylate cyclase, resulting in decreased cyclic guanosine monophosphate (cGMP) levels. Low cGMP contributes to vascular dysfunction, increased cardiac workload, and progressive worsening of heart failure.

Vericiguat works by directly stimulating soluble guanylate cyclase, both independently of and synergistically with nitric oxide. This stimulation increases intracellular cGMP levels, leading to improved vascular relaxation, reduced cardiac stress, enhanced myocardial function, and better overall cardiovascular performance. Through this mechanism, Cardiver Tablet helps stabilize heart failure and slow disease progression.

Therapeutic Uses

Cardiver Tablet 2.5 mg is indicated for:

• Chronic heart failure with reduced ejection fraction

• Patients with symptomatic heart failure following recent decompensation

• Reduction of risk of heart failure-related hospitalization

• Long-term management of cardiovascular function under specialist supervision

It is typically used in combination with other standard heart failure therapies, such as beta-blockers, ACE inhibitors, ARBs, or mineralocorticoid receptor antagonists.

Dosage and Administration

• The usual starting dose is 2.5 mg once daily, taken with food.

• Based on patient tolerance and clinical response, the dose may be gradually increased as directed by a physician.

• Tablets should be swallowed whole with water and should not be crushed or chewed.

• Treatment should be continued regularly as prescribed for optimal benefit.

Patients should not alter the dose or discontinue therapy without consulting their healthcare provider.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Benefits of Cardiver Tablet

• Targets a key pathway involved in heart failure progression

• Helps reduce hospitalization risk in chronic heart failure patients

• Improves vascular function and cardiac efficiency

• Suitable for long-term management under medical supervision

• Can be used alongside standard heart failure medications

Possible Side Effects

Some patients may experience side effects, including:

• Low blood pressure (hypotension)

• Dizziness or lightheadedness

• Anemia

• Headache

Most side effects are mild to moderate. Patients should inform their physician if symptoms persist or worsen.

Precautions and Warnings

• Use with caution in patients with low blood pressure or severe renal impairment.

• Not recommended during pregnancy due to potential risk to the fetus.

• Avoid use with other medications that strongly affect nitric oxide pathways unless advised by a physician.

• Regular monitoring of blood pressure and clinical status is recommended.

Storage Instructions

• Store below 25°C in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children

• Do not use after the expiry date.