Carlina-M Tablet 2.5 mg + 500 mg is a combination oral antidiabetic medication containing Linagliptin 2.5 mg and Metformin Hydrochloride 500 mg. This combination is designed for adults with type 2 diabetes mellitus who require better blood glucose control. By combining two complementary mechanisms of action, Carlina-M helps reduce both fasting and postprandial blood sugar levels while supporting overall glycemic management.

Linagliptin is a DPP-4 (dipeptidyl peptidase-4) inhibitor, which enhances the body’s natural incretin hormones. These hormones increase insulin secretion in response to elevated blood glucose and suppress glucagon release from the pancreas, helping lower blood sugar levels.

Metformin Hydrochloride is a biguanide class antidiabetic that reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity in peripheral tissues. The combination of these two agents provides a synergistic effect on blood glucose regulation, making it easier to achieve target HbA1c levels in patients inadequately controlled by diet, exercise, or monotherapy.

Carlina-M is especially suitable for patients who need dual therapy to manage hyperglycemia while minimizing the risk of hypoglycemia and weight gain.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Oral Antidiabetic Agent
DPP-4 Inhibitor + Biguanide Combination

Indications

Carlina-M Tablet is indicated for:

• Adults with type 2 diabetes mellitus inadequately controlled with diet and exercise

• Patients requiring dual therapy to achieve glycemic targets

• Can be used as add-on therapy for patients already on Metformin or Linagliptin monotherapy

• Helps in reducing fasting and postprandial glucose levels

It is not indicated for type 1 diabetes or diabetic ketoacidosis.

Mechanism of Action

Linagliptin:

• Inhibits DPP-4 enzyme, preventing the breakdown of incretin hormones

• Incretins increase insulin secretion in response to glucose

• Suppresses glucagon secretion, reducing hepatic glucose output

Metformin Hydrochloride:

• Decreases hepatic gluconeogenesis

• Reduces intestinal glucose absorption

• Improves insulin sensitivity in muscle and fat tissues

The combination provides complementary and synergistic effects, resulting in improved glycemic control with low risk of hypoglycemia.

Dosage and Administration

• Usually taken twice daily with meals to reduce gastrointestinal side effects

• Swallow the tablet whole with water; do not crush or chew

• Dosage may be adjusted based on blood glucose levels, renal function, and physician’s advice

• Regular monitoring of blood glucose, HbA1c, and renal function is recommended

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Carlina-M is generally well tolerated. Common side effects may include:

• Gastrointestinal discomfort (nausea, vomiting, diarrhea, abdominal pain)

• Headache

• Mild dizziness

Rare but serious side effects may include lactic acidosis (primarily from Metformin), hypoglycemia (especially when used with other antidiabetic agents), or allergic reactions. Patients should seek medical attention if severe symptoms occur.

Precautions and Warnings

• Avoid in patients with severe renal impairment, hepatic dysfunction, or metabolic acidosis

• Monitor renal function before and during therapy

• Discontinue before radiologic studies involving iodinated contrast media

• Not recommended during pregnancy or lactation unless prescribed by a physician

• Adherence to diet and lifestyle modifications is essential

Storage

• Store in a cool, dry place below 30°C

• Keep the container tightly closed

• Protect from moisture and light

• Keep out of reach of children.