Cetuxim Injection 5 mg/ml contains Cetuximab, a monoclonal antibody used in the treatment of certain types of cancers. It specifically targets the epidermal growth factor receptor (EGFR), which is involved in tumor cell growth and survival. Cetuximab is commonly used in metastatic colorectal cancer and head and neck cancers as part of combination therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Cetuximab 5 mg/ml
• Dosage Form: Sterile intravenous infusion solution
• Route: Intravenous use only

Mechanism of Action

Cetuximab binds specifically to the extracellular domain of the EGFR receptor, blocking activation by natural ligands. This inhibits downstream signaling pathways responsible for cancer cell proliferation, survival, angiogenesis, and metastasis. It also promotes immune-mediated destruction of tumor cells through antibody-dependent cellular cytotoxicity (ADCC).

Indications

Cetuxim Injection is indicated for:

• Metastatic colorectal cancer (KRAS wild-type)
• Squamous cell carcinoma of the head and neck
• Locally advanced or recurrent head and neck cancers
• Combination therapy with chemotherapy or radiotherapy as prescribed

Dosage and Administration

• Administered only under the supervision of an oncologist
• Given as intravenous infusion with a loading dose followed by maintenance doses
• Dose is based on body surface area and treatment protocol
• Infusion should be performed in a controlled medical setting
• Pre-medication may be required to reduce infusion reactions

Precautions

• Risk of severe infusion-related reactions
• Monitor for skin reactions (acne-like rash is common)
• Use with caution in patients with cardiac or pulmonary disease
• Electrolyte imbalance (especially magnesium) may occur
• Not recommended during pregnancy unless clearly necessary

Side Effects

Common side effects include:

• Skin rash (acneiform eruption)
• Fatigue
• Diarrhea
• Nausea
• Infusion reactions (fever, chills)

Serious side effects:

• Severe hypersensitivity reactions
• Cardiorespiratory complications
• Severe electrolyte disturbances (hypomagnesemia)
• Infections due to immunosuppression

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store at 2°C to 8°C in a refrigerator
• Do not freeze or shake
• Protect from light
• Keep out of reach of children

Conclusion

Cetuxim Injection 5 mg/ml (Cetuximab) is a targeted monoclonal antibody therapy used in the treatment of EGFR-positive cancers. It helps inhibit tumor growth and improve outcomes when used under strict oncological supervision.