Cozid Injection 500 mg/vial contains Ceftazidime Pentahydrate, a third-generation cephalosporin antibiotic used for the treatment of a wide range of moderate to severe bacterial infections. It is administered via intravenous (IV) or intramuscular (IM) route and is commonly used in clinical and hospital settings. This lower strength formulation is suitable for pediatric dosing, mild to moderate infections, or dose-adjusted therapy in special patient populations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Ceftazidime (as Ceftazidime Pentahydrate) 500 mg

Mechanism of Action

Ceftazidime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan chains in bacterial cell walls. This inhibition weakens the structural integrity of the bacteria, leading to cell lysis and death. It is particularly effective against gram-negative organisms, including Pseudomonas aeruginosa, making it valuable in serious and resistant infections.

Indications

Cozid Injection 500 mg/vial is indicated for the treatment of:

• Respiratory tract infections (bronchitis, pneumonia)
• Urinary tract infections (UTIs)
• Skin and soft tissue infections
• Ear, nose, and throat infections
• Bone and joint infections (mild to moderate cases)
• Intra-abdominal infections (in combination therapy)
• Septicemia caused by susceptible organisms
• Pediatric bacterial infections requiring parenteral therapy

Dosage and Administration

• Administered only by IV or IM injection under medical supervision
• Dosage varies depending on infection type, severity, age, and renal function
• Common adult dosing may range from 1–6 g per day in divided doses (adjusted using 500 mg vial when needed)
• Pediatric dosing is weight-based and must be strictly calculated by a physician
• Dose adjustment is required in renal impairment
• Reconstitution should be done with sterile water for injection or as directed in clinical guidelines

Contraindications

Cozid Injection should not be used in patients with:

• Known hypersensitivity to Ceftazidime or other cephalosporins
• Severe allergic reactions to penicillin-class antibiotics
• Uncontrolled severe sodium restriction cases without supervision

Side Effects

Possible side effects include:

• Pain or swelling at injection site
• Rash or allergic skin reactions
• Nausea, vomiting, or diarrhea
• Temporary elevation of liver enzymes
• Blood-related changes such as leukopenia or eosinophilia (rare)
• Neurological effects such as seizures in high doses or renal impairment

Precautions

• Use cautiously in patients with a history of beta-lactam allergy
• Monitor renal function during prolonged therapy
• Adjust dose carefully in kidney impairment
• Risk of superinfection with long-term antibiotic use
• Must be used under strict medical supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Cozid Injection may interact with:

• Aminoglycosides (increased risk of kidney toxicity)
• Loop diuretics such as furosemide
• Chloramphenicol (possible reduced antibacterial effect)
• Anticoagulants (may affect coagulation parameters)

Storage Conditions

• Store below 25°C in a cool, dry place
• Protect from light and moisture
• Use freshly prepared solution as directed
• Keep out of reach of children