Cytabin Injection 500 mg/vial contains Cytarabine, a potent antimetabolite chemotherapeutic agent widely used in the treatment of hematological malignancies. It is an essential component of many standard chemotherapy regimens, especially for leukemia. Cytarabine works by inhibiting DNA synthesis in rapidly dividing cancer cells, thereby preventing their growth and multiplication.

This injectable formulation is administered in hospital settings under strict medical supervision due to its potent cytotoxic effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Cytarabine 500 mg

Mechanism of Action

Cytarabine is a pyrimidine nucleoside analog that is converted inside the body into its active metabolite, cytarabine triphosphate. This active form inhibits DNA polymerase, an enzyme essential for DNA replication. As a result, it blocks the synthesis of new DNA strands, leading to inhibition of cell division and eventual death of rapidly proliferating malignant cells, particularly in bone marrow and blood-forming tissues.

Indications

Cytabin Injection 500 mg/vial is indicated for the treatment of:

• Acute myeloid leukemia (AML)
• Acute lymphoblastic leukemia (ALL)
• Chronic myelogenous leukemia (blast crisis phase)
• Non-Hodgkin lymphoma (as part of combination therapy)
• Meningeal leukemia (intrathecal use in specialized protocols)
• Other hematologic malignancies as per oncology guidelines

Dosage and Administration

• Administered only under supervision of a qualified oncologist
• Routes of administration include intravenous (IV), subcutaneous (SC), or intrathecal (in specialized settings)
• Dosage depends on disease type, treatment protocol, body surface area, and patient condition
• Requires strict monitoring of blood counts during therapy
• Dose adjustments may be required in hepatic or renal impairment
• Intrathecal administration must only be performed by trained specialists

Contraindications

Cytabin Injection should not be used in:

• Known hypersensitivity to Cytarabine
• Severe bone marrow suppression unless part of controlled chemotherapy protocol
• Active uncontrolled infections without appropriate management
• Pregnancy and lactation unless clearly advised by a specialist

Side Effects

Possible side effects include:

• Bone marrow suppression (leukopenia, thrombocytopenia, anemia)
• Nausea and vomiting
• Fever and fatigue
• Mouth ulcers (stomatitis)
• Liver function abnormalities
• Hair loss (alopecia)
• Cerebellar toxicity (high-dose therapy, especially in elderly patients)
• Injection site reactions

Precautions

• Regular monitoring of complete blood count is essential
• Neurological assessment is recommended during high-dose therapy
• Use cautiously in elderly patients and those with hepatic or renal impairment
• Risk of severe infections due to immunosuppression
• Strict aseptic technique required for administration
• Should only be used in hospital or oncology settings

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Cytabin Injection may interact with:

• Other myelosuppressive agents (increased toxicity)
• Digoxin (reduced absorption or effect)
• Immunosuppressants (additive immunosuppression)
• Fluorocytosine (reduced antifungal efficacy)

Storage Conditions

• Store below 25°C in a cool, dry place
• Protect from light
• Do not freeze
• Keep out of reach of children.