Dacarzin Injection 200 mg/vial contains Dacarbazine, an antineoplastic (chemotherapy) agent belonging to the class of alkylating-like drugs. It is widely used in oncology for the treatment of malignant melanoma and Hodgkin’s lymphoma, as well as certain soft tissue sarcomas. Dacarbazine works by interfering with DNA synthesis in cancer cells, leading to inhibition of tumor growth.

This injectable formulation is administered in hospital settings under strict medical supervision due to its cytotoxic nature.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Dacarbazine 200 mg

Mechanism of Action

Dacarbazine is a prodrug that undergoes hepatic activation to form reactive metabolites. These metabolites exert cytotoxic effects by methylating DNA, thereby disrupting DNA replication and transcription. This leads to cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells.

Indications

Dacarzin Injection 200 mg/vial is indicated for the treatment of:

• Malignant melanoma
• Hodgkin’s lymphoma (as part of combination therapy)
• Soft tissue sarcomas
• Certain metastatic cancers as per oncology protocols
• Other malignancies as determined by a specialist physician

Dosage and Administration

• Administered only under the supervision of a qualified oncologist
• Given by intravenous (IV) route only after proper reconstitution
• Dosage is based on body surface area, disease type, and treatment protocol
• Usually administered in cycles as part of combination chemotherapy
• Dose adjustment may be required in hepatic or renal impairment
• Blood counts and liver function must be monitored regularly during therapy

Contraindications

Dacarzin Injection should not be used in:

• Known hypersensitivity to Dacarbazine
• Severe bone marrow suppression
• Active serious infections without proper management
• Pregnancy and breastfeeding unless clearly necessary under specialist supervision

Side Effects

Possible side effects include:

• Bone marrow suppression (leukopenia, thrombocytopenia, anemia)
• Nausea and vomiting (common)
• Flu-like symptoms (fever, fatigue, muscle pain)
• Loss of appetite
• Liver function abnormalities
• Injection site irritation
• Rare risk of severe hepatic toxicity or veno-occlusive disease

Precautions

• Administer only in hospital settings with oncology supervision
• Regular monitoring of CBC and liver function tests is essential
• Use cautiously in patients with hepatic or renal impairment
• Adequate antiemetic support is often required due to high emetogenic potential
• Avoid use during pregnancy unless absolutely necessary

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Dacarzin Injection may interact with:

• Other myelosuppressive agents (increased toxicity)
• Hepatotoxic drugs (increased liver risk)
• Alcohol (may worsen liver toxicity)
• Enzyme-modifying drugs affecting hepatic metabolism

Storage Conditions

• Store below 25°C in a cool, dry place
• Protect from light
• Do not freeze
• Keep out of reach of children.