Dexochol 300 mg Capsule contains Ursodeoxycholic Acid (UDCA), a naturally occurring bile acid used in the treatment of various hepatobiliary disorders. It is widely prescribed for conditions associated with cholestasis, liver dysfunction, and cholesterol gallstones.

Dexochol works by improving bile flow, reducing cholesterol saturation in bile, and protecting liver cells from bile acid–induced injury. It is an effective therapeutic option in both acute and chronic liver conditions, helping restore liver function and reduce complications associated with impaired bile secretion.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Anti-gallstones drugs: Bile Acids

Pharmacology

Ursodeoxycholic Acid in Dexochol 300 mg reduces cholesterol concentration in bile and alters bile composition from supersaturated to unsaturated, promoting gallstone dissolution. Its mechanism of action includes:

• Reducing intestinal absorption of cholesterol

• Suppressing hepatic cholesterol synthesis

• Promoting formation of liquid cholesterol crystal complexes, facilitating removal of cholesterol from the gallbladder

• Protecting cholangiocytes against the cytotoxic effects of hydrophobic bile acids

• Stimulating hepatobiliary secretion

• Protecting hepatocytes from bile acid-induced apoptosis

Dexochol is completely absorbed in the upper intestine, reaching peak serum concentration within 30–150 minutes. Approximately 60–80% is absorbed and extracted by the liver via the portal vein. It is conjugated with glycine or taurine and secreted into bile ducts. The biological half-life ranges from 3.5 to 5.8 days. Only small amounts are excreted in urine.

Indications

Dexochol 300 mg is indicated for the treatment of:

• Cholestasis (Jaundice)

• Acute Viral Hepatitis

• Alcoholic Fatty Liver Disease

• Primary Biliary Cirrhosis (PBC)

• Primary Sclerosing Cholangitis (PSC)

• Dissolution of cholesterol gallstones

• Non-Alcoholic Steatohepatitis (NASH)

Dosage and Administration

Dosage depends on the condition being treated:

• Gallstone dissolution: 8–12 mg/kg/day (single nighttime dose or divided doses)

• Primary Biliary Cirrhosis (PBC): 10–15 mg/kg/day in 2–4 divided doses

• Acute Viral Hepatitis: 600 mg/day

• Alcoholic Fatty Liver: 300 mg/day

• Primary Sclerosing Cholangitis (PSC): 25–30 mg/kg/day

• Non-Alcoholic Steatohepatitis (NASH): 13–15 mg/kg/day

Dosage should be individualized based on body weight and clinical response, under physician supervision.

Drug Interactions

Dexochol 300 mg should not be used with:

• Oestrogenic hormones, which increase bile cholesterol

• Bile acid-binding agents such as cholestyramine, antacids containing aluminum, and activated charcoal, as they reduce UDCA absorption and effectiveness

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Non-functioning gallbladder

• Calcified or pigmented gallstones

• Inflammatory bowel disease

• Hypersensitivity to Ursodeoxycholic Acid

Side Effects

Common side effects may include:

• Nausea

• Vomiting

• Diarrhoea

• Pruritus

• Gallstone opacification

These effects are generally mild and reversible upon discontinuation.

Pregnancy and Lactation

• Pregnancy Category B

• No evidence of harm reported in pregnancy

• Commonly used for cholestasis of pregnancy, especially in the last trimester

• No documented problems during breastfeeding

Precautions and Warnings

• Use cautiously in patients with advanced liver disease

• Regular monitoring of liver function tests (LFTs) is recommended during long-term therapy

• Ultrasound monitoring may be required during gallstone treatment

Storage Conditions

• Store below 25°C

• Protect from light and moisture

• Keep out of reach of children.