Dolonil Injection 100 mg/2 ml contains Tramadol Hydrochloride, a centrally acting analgesic used for the management of moderate to moderately severe pain. This parenteral formulation is intended for intravenous (IV) or intramuscular (IM) administration, providing rapid onset of pain relief, particularly in situations where oral administration is not feasible, such as post-operative pain, trauma, or severe acute pain episodes.

Tramadol is a synthetic opioid analgesic that combines opioid receptor agonism with inhibition of norepinephrine and serotonin reuptake, resulting in effective pain modulation. Dolonil Injection offers reliable and fast-acting analgesia while minimizing the need for high oral doses. It is commonly used in hospital and clinical settings under professional supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Tramadol Hydrochloride: 100 mg per 2 ml

Indications

Dolonil Injection 100 mg/2 ml is indicated for:

• Acute post-operative pain

• Moderate to severe musculoskeletal pain

• Pain management in trauma and injury

• Pain associated with fractures or surgical procedures

• Cases where oral analgesics are not suitable or effective

Mechanism of Action

Tramadol hydrochloride exerts its analgesic effect through a dual mechanism:

1. Opioid receptor agonism: Tramadol binds to μ-opioid receptors in the central nervous system, inhibiting pain signaling pathways.

2. Monoamine reuptake inhibition: It inhibits the reuptake of norepinephrine and serotonin, enhancing descending inhibitory pain pathways in the spinal cord.

This combination provides effective pain relief while reducing the risks associated with stronger opioids, such as respiratory depression, when used appropriately.

Dosage and Administration

• Route: Intravenous (IV) or intramuscular (IM)

• Dosage: As prescribed by a registered physician

The recommended dose varies based on patient age, weight, severity of pain, and clinical condition. For IV administration, Dolonil should be injected slowly to reduce the risk of adverse reactions. IM administration should be performed in a large muscle group to ensure adequate absorption. Dose adjustments may be necessary in elderly patients or those with renal or hepatic impairment.

Benefits of Dolonil Injection 100 mg/2 ml

• Rapid and effective relief from moderate to severe pain

• Suitable for patients unable to take oral medications

• Dual mechanism of action enhances analgesic efficacy

• Convenient pre-measured injection for precise dosing

• Useful in hospital and post-operative pain management

• Reduces the need for stronger opioids when used appropriately

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under medical supervision

• Contraindicated in patients with known hypersensitivity to tramadol

• Caution in patients with respiratory depression, epilepsy, or history of substance abuse

• Avoid concomitant use with MAO inhibitors, SSRIs, or other CNS depressants unless directed by a physician

• Monitor for side effects such as nausea, dizziness, constipation, or hypotension

• Not recommended for pediatric patients below certain age limits unless prescribed

Storage Conditions

• Store below 30°C in a dry place

• Protect from light

• Keep out of reach of children

Pharmaceutical Category

Opioid Analgesic.