Don-A Tablet 10 mg contains Domperidone Maleate, a gastrointestinal prokinetic and antiemetic widely used to treat nausea, vomiting, and delayed gastric emptying. This oral tablet formulation is convenient for adults and older children who can swallow tablets, providing effective relief from gastrointestinal discomfort while improving overall digestive function.

Domperidone works by blocking dopamine D2 receptors in the gastrointestinal tract and the chemoreceptor trigger zone (CTZ), enhancing gastric motility and promoting faster emptying of the stomach. It also helps reduce nausea and vomiting caused by various conditions, including infections, migraines, or medication-related side effects. Its minimal penetration into the central nervous system reduces the risk of sedation and neurological adverse effects, making it a well-tolerated and safe option for many patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Domperidone Maleate: 10 mg per tablet

Indications

Don-A Tablet 10 mg is indicated for:

• Relief of nausea and vomiting in adults and children above a specified age

• Management of gastroesophageal reflux (GER) symptoms such as regurgitation and vomiting

• Treatment of delayed gastric emptying (gastroparesis)

• Prevention of vomiting associated with migraine, infections, or medication use

• Supportive therapy for digestive discomfort in patients requiring oral tablets

Mechanism of Action

Domperidone exerts its therapeutic effects through peripheral dopamine D2 receptor antagonism:

1. Enhanced gastrointestinal motility: Increases peristalsis and accelerates gastric emptying, reducing bloating and discomfort.

2. Anti-nausea effect: Blocks dopamine receptors in the chemoreceptor trigger zone (CTZ), preventing signals that trigger vomiting.

3. Peripheral action: Minimal central nervous system penetration reduces sedation, making it suitable for long-term use in patients with gastrointestinal issues.

This dual action ensures both symptom relief and improved gastrointestinal function.

Dosage and Administration

• Route: Oral

• Dosage: As prescribed by a registered physician

The usual adult dose is 10 mg taken 3–4 times daily, 15–30 minutes before meals, with an additional dose at bedtime if necessary. Dosage may vary for elderly patients or those with renal or hepatic impairment, and should always be adjusted according to medical guidance. Tablets should be swallowed whole with water and not chewed.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Benefits of Don-A Tablet 10 mg

• Effective relief of nausea, vomiting, and gastric discomfort

• Improves gastric motility and digestive function

• Safe and well-tolerated for adults and older children

• Convenient oral tablet for precise dosing

• Minimizes central nervous system side effects compared to other antiemetics

• Supports better tolerance of meals and overall gastrointestinal health

Precautions and Warnings

• Use only under medical supervision

• Not recommended for children below 12 years unless prescribed

• Caution in patients with heart rhythm disorders, liver disease, or renal impairment

• Avoid concomitant use with medications that prolong QT interval

• Monitor for side effects such as abdominal cramps, diarrhea, headache, or dizziness

• Pregnant or breastfeeding women should consult a physician before use

Storage Conditions

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

Pharmaceutical Category

Gastrointestinal Prokinetic / Antiemetic.