Dulong 30 mg contains dapoxetine, a short-acting selective serotonin reuptake inhibitor (SSRI) specifically developed for the treatment of premature ejaculation (PE) in adult men. It helps improve control over ejaculation, increase the time to ejaculation, and reduce distress or interpersonal difficulties associated with PE.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Dulong 30 mg is indicated for the treatment of premature ejaculation in men aged 18 to 64 years who have:

• Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes

• Marked personal distress or interpersonal difficulty due to premature ejaculation

• Poor control over ejaculation

It is prescribed only when the condition significantly affects quality of life and relationships.

Therapeutic Class

• Drugs for Erectile Dysfunction

Pharmacology

Dapoxetine works by inhibiting the neuronal reuptake of serotonin (5-HT), thereby increasing serotonin activity in the nervous system. Serotonin plays an important inhibitory role in ejaculation.

The ejaculatory process involves a complex neural network that includes spinal and cerebral centers. These centers coordinate sympathetic, parasympathetic, and somatic responses during sexual activity.

By increasing serotonin levels in descending brain pathways, dapoxetine enhances inhibitory control over ejaculation. Three serotonin receptor subtypes are believed to contribute to this effect:

• 5-HT1A

• 5-HT1B

• 5-HT2C

Through modulation of these pathways, Dulong 30 mg helps delay ejaculation and improve sexual satisfaction.

Dosage & Administration

Adults (18–64 years):

• Recommended starting dose: 30 mg, taken as needed approximately 1 to 3 hours before sexual activity

• If 30 mg is insufficient and side effects are tolerable, the dose may be increased to 60 mg

• Maximum recommended frequency: One dose every 24 hours

It should be swallowed whole with a full glass of water to reduce the risk of dizziness or fainting.

Drug Interactions

Caution is advised when used with:

• CNS active medicinal products (limited evaluation in PE patients)

• PDE5 inhibitors (e.g., sildenafil, tadalafil): May reduce orthostatic tolerance

• Alpha-blockers (e.g., tamsulosin): Increased risk of orthostatic hypotension

• Warfarin: Use cautiously due to limited data

• Alcohol: Increases risk of dizziness, drowsiness, slow reflexes, syncope, and accidental injury

Concomitant use with the following is contraindicated:

• Monoamine oxidase inhibitors (MAOIs)

• Thioridazine

• SSRIs, SNRIs, TCAs

• Other serotonergic medicinal or herbal products

Proper washout periods must be observed.

Contraindications

Dulong 30 mg is contraindicated in patients with:

• Known hypersensitivity to dapoxetine

• Significant cardiac conditions (e.g., heart failure NYHA class II–IV, conduction abnormalities without pacemaker, ischemic heart disease, significant valvular disease)

• Concomitant treatment with MAOIs or thioridazine

• Concomitant use of serotonergic antidepressants

Side Effects

Common side effects include:

• Dizziness

• Headache

• Somnolence

• Tremor

• Blurred vision

• Tinnitus

• Nausea

• Diarrhea

• Abdominal pain

• Dry mouth

• Fatigue

• Insomnia

• Hypertension

Most adverse effects are mild to moderate and dose-related.

Precautions & Warnings

Use cautiously in patients with:

• Bleeding disorders

• Epilepsy

• Susceptibility to angle-closure glaucoma

• Raised intraocular pressure

• Known CYP2D6 poor metabolizers

Patients should avoid alcohol while taking this medication due to increased risk of adverse effects and fainting.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Overdose

In studies, doses up to 240 mg did not produce unexpected adverse effects. Overdose symptoms may include:

• Somnolence

• Nausea and vomiting

• Tachycardia

• Tremor

• Agitation

• Dizziness

Supportive treatment should be provided as necessary.

Pregnancy & Lactation

Dapoxetine is not indicated for use in women. It is unknown whether dapoxetine or its metabolites are excreted in breast milk.

Storage Conditions

• Store below 30°C

• Protect from light and moisture

• Keep out of reach of children.