Eval CR Tablet 500 mg is a controlled-release formulation containing Sodium Valproate, a well-established anticonvulsant and mood-stabilizing medication. It is primarily used for the management of epilepsy, including generalized tonic-clonic seizures, absence seizures, and complex partial seizures. Additionally, it is indicated for bipolar disorder to control manic episodes and stabilize mood, as well as for migraine prophylaxis.

The controlled-release (CR) technology in Eval CR Tablet 500 mg ensures gradual and sustained absorption of Sodium Valproate, maintaining stable blood levels over an extended period. This reduces peak-related side effects, enhances therapeutic efficacy, and allows once- or twice-daily dosing, improving patient adherence and convenience for long-term therapy.

Epilepsy and bipolar disorder are chronic neurological and psychiatric conditions that significantly affect daily life. Seizures can cause physical injury, cognitive impairment, and reduced quality of life, while mood instability in bipolar disorder can lead to emotional distress and functional impairment. Eval CR Tablet 500 mg helps stabilize neuronal activity, control seizures, manage mood swings, and improve overall patient well-being.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features and Benefits

Active Ingredient:

• Sodium Valproate 500 mg per controlled-release tablet

Effective Seizure Control:

• Reduces frequency and severity of generalized tonic-clonic, absence, and complex partial seizures

• Suitable for monotherapy or adjunctive therapy

• Helps prevent recurrence of seizures with long-term use

Mood Stabilization:

• Manages manic and mixed episodes in bipolar disorder

• Reduces emotional instability and mood swings

• Supports better mental health and quality of life

Migraine Prophylaxis:

• Reduces frequency, intensity, and duration of migraine attacks

• Supports improved daily functioning

Controlled-Release Technology:

• Provides steady release of medication over time

• Minimizes peak-related side effects such as dizziness, drowsiness, and gastrointestinal discomfort

• Enhances adherence with once- or twice-daily dosing

How It Works

Sodium Valproate regulates brain activity through multiple mechanisms:

1. Enhancement of GABA activity: Increases levels of gamma-aminobutyric acid (GABA), the brain’s inhibitory neurotransmitter, calming overactive neurons.

2. Modulation of ion channels: Blocks voltage-gated sodium and calcium channels, preventing abnormal electrical discharges that cause seizures.

3. Neuroprotective effects: Protects neurons from excitotoxicity associated with repeated seizures.

The controlled-release formulation maintains a stable plasma concentration, enhancing therapeutic outcomes while minimizing side effects associated with peak doses.

Indications

Eval CR Tablet 500 mg is indicated for:

• Generalized tonic-clonic seizures

• Absence seizures

• Complex partial seizures

• Bipolar disorder (manic and mixed episodes)

• Migraine prophylaxis

Dosage and Administration

• Take orally as prescribed by a healthcare professional, preferably with food to reduce gastrointestinal irritation.

• Swallow the tablet whole; do not crush, chew, or break it to preserve the controlled-release mechanism.

• The dose is individualized based on clinical response, age, weight, and coexisting medical conditions.

• Regular monitoring of liver function, blood counts, and plasma levels is recommended during long-term therapy.

• Do not abruptly discontinue therapy to avoid seizure recurrence or mood destabilization.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Safety Information

• Inform your doctor if you have liver disease, kidney impairment, pancreatitis, or hematological disorders.

• Common side effects may include nausea, vomiting, drowsiness, dizziness, tremor, and weight gain.

• Rare but serious adverse effects include hepatotoxicity, pancreatitis, thrombocytopenia, and severe allergic reactions. Seek immediate medical attention if these occur.

• Avoid alcohol as it may enhance drowsiness and impair seizure control.

• Use caution when performing tasks requiring alertness, such as driving or operating machinery.

Storage Instructions

• Store below 30°C in a cool, dry place.

• Keep the container tightly closed, protected from light and moisture.

• Keep out of reach of children.

Eval CR Tablet 500 mg provides reliable seizure control, mood stabilization, and migraine prevention through its controlled-release mechanism. Its steady plasma levels, convenient dosing schedule, and effective therapeutic action make it suitable for long-term management of epilepsy, bipolar disorder, and migraine prophylaxis under medical supervision.