Febustat 40 mg is a prescription medication used for the chronic management of hyperuricemia in patients with gout. It is a non-purine, selective xanthine oxidase (XO) inhibitor that works by reducing uric acid production in the body. By lowering serum uric acid levels, Febustat helps prevent the formation of urate crystals, reducing the risk of gout attacks and associated complications.

Febustat 40 mg is not recommended for asymptomatic hyperuricemia and should be used only under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

• Chronic management of hyperuricemia in patients with gout

• Prevention of urate crystal deposition and subsequent gout flares in individuals with elevated uric acid levels

Pharmacology

Febustat 40 mg selectively inhibits xanthine oxidase, the enzyme responsible for converting hypoxanthine to xanthine and xanthine to uric acid. Unlike some other urate-lowering agents, Febustat does not interfere with other enzymes involved in purine or pyrimidine metabolism at therapeutic doses, making it highly specific for controlling uric acid levels.

Dosage and Administration

• Recommended Dose: 40 mg or 80 mg once daily

• Starting Dose: 40 mg once daily

• Titration: If serum uric acid remains above 6 mg/dL after 2 weeks, the dose may be increased to 80 mg once daily

• Febustat 40 mg can be taken with or without food

• Renal and Hepatic Impairment: No dose adjustment required in mild to moderate cases

• Administer consistently at the same time each day for optimal effect

Mode of Action

Febustat reduces uric acid levels by inhibiting xanthine oxidase, thereby preventing the conversion of hypoxanthine and xanthine into uric acid. This decreases uric acid accumulation, lowering the risk of crystal deposition in joints and soft tissues, which is responsible for gout flares and complications.

Contraindications

• Hypersensitivity to Febustat or its components

• Concurrent use with azathioprine, mercaptopurine, or theophylline, due to risk of severe toxicity

Drug Interactions

• Azathioprine, mercaptopurine, theophylline: Co-administration may increase plasma levels of these drugs

• Febustat should be used cautiously with medications that affect uric acid metabolism

Side Effects

Common adverse reactions include:

• Liver enzyme abnormalities (transaminase elevation)

• Nausea

• Arthralgia (joint pain)

• Rash

Precautions:

• Monitor for gout flares during initial therapy; prophylactic NSAIDs or colchicine may be considered for up to 6 months

• Cardiovascular events: Higher risk of thromboembolic events compared to allopurinol; monitor for MI or stroke

• Periodic liver function tests recommended

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Overdose

• Doses up to 300 mg daily for 7 days in studies showed no dose-limiting toxicity

• Symptomatic and supportive care recommended in case of overdose

Pregnancy and Lactation

• Pregnancy Category C: Use only if benefits outweigh risks

• Unknown if excreted in breast milk; caution is advised for nursing mothers

Pediatric and Geriatric Use

• Pediatric: Safety and efficacy not established in patients under 18 years

• Geriatric: No significant differences observed; monitor for comorbidities

Storage Conditions

• Store below 30°C, protected from light and moisture

• Keep out of reach of children

Summary

Febustat 40 mg is a selective xanthine oxidase inhibitor designed for the chronic management of hyperuricemia in gout patients. By reducing uric acid production, it helps prevent gout flares and urate crystal deposition. Regular monitoring and adherence to dosing instructions ensure safe and effective therapy.