Fenofex Syrup 50 ml contains Fexofenadine Hydrochloride, a second-generation, non-sedating antihistamine formulated especially for convenient use in children and patients who prefer liquid dosage forms. It is widely used for the effective relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria. Fenofex Syrup provides fast, long-lasting relief from allergy symptoms without causing significant drowsiness, making it suitable for daytime use.

Allergic conditions such as seasonal and persistent allergic rhinitis can significantly impair daily activities, sleep quality, and overall well-being. Fenofex Syrup helps control common allergy symptoms including sneezing, runny nose, watery eyes, nasal and throat itching, and skin itching. By reducing these symptoms, it improves both work or school productivity and health-related quality of life in affected patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Non-sedating Antihistamines

Indications

Fenofex Syrup 50 ml is indicated for the treatment of:

• Allergic rhinitis (seasonal and persistent) in adults and children

  • Sneezing

  • Rhinorrhea

  • Lacrimation

  • Itchy, red eyes

  • Itching of the nose, palate, and throat

• Chronic idiopathic urticaria in adults and children

  • Reduction in wheals

  • Relief from pruritus

Pharmacology

Fexofenadine is a selective peripheral H1-receptor antagonist. After oral administration, it is rapidly absorbed and reaches peak plasma concentrations within 2 to 3 hours. Unlike first-generation antihistamines, fexofenadine does not readily cross the blood-brain barrier, which explains its minimal sedative effect and low risk of cognitive impairment.

Mode of Action

Allergic reactions occur when histamine is released from mast cells and basophils following allergen exposure. Histamine binds to H1 receptors, triggering symptoms such as itching, nasal discharge, and watery eyes. Fexofenadine acts as an inverse agonist at H1 receptors, stabilizing them in an inactive state and preventing the downstream inflammatory cascade. It has no significant anticholinergic, sedative, or central nervous system depressant effects.

Dosage & Administration

Allergic Rhinitis and Chronic Idiopathic Urticaria

• Adults and children ≥12 years:

  • 60 mg twice daily or

  • 120 mg once daily or

  • 180 mg once daily

• Children 2–11 years:

  • 30 mg (5 ml) twice daily

• Children 6 months to <2 years (urticaria):

  • 15 mg (2.5 ml) twice daily

• In renal impairment: reduced once-daily dosing is recommended

Dosage should be adjusted according to age, clinical response, and renal function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Fenofex Syrup has minimal interaction potential as it does not undergo hepatic metabolism. Co-administration with erythromycin or ketoconazole may increase plasma levels without clinical significance. Antacids containing aluminum or magnesium hydroxide may reduce absorption; a 2-hour interval between dosing is advised.

Contraindications

Fenofex Syrup is contraindicated in patients with known hypersensitivity to fexofenadine or any of its ingredients.

Side Effects

Fenofex is generally well tolerated. Common side effects include:

• Headache

• Fatigue

• Dizziness

• Nausea

Rare post-marketing effects include hypersensitivity reactions, palpitations, insomnia, rash, urticaria, and pruritus.

Pregnancy & Lactation

Fenofex Syrup is classified as Pregnancy Category C. Its use during pregnancy and breastfeeding is not recommended unless clearly necessary and advised by a physician.

Precautions & Warnings

Caution is advised in elderly patients and those with renal impairment or cardiovascular disease. Fenofex is unlikely to impair the ability to drive or operate machinery, though individual sensitivity should be considered.

Storage Conditions

Store in a dry place away from heat and light. Keep out of the reach of children.