Flexifen 10 mg Tablet is a centrally acting skeletal muscle relaxant used for the management of spasticity and muscle spasms associated with neurological and musculoskeletal disorders. It is particularly effective in relieving muscle stiffness, flexor spasms, pain, and clonus, helping to improve mobility and quality of life in affected patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Flexifen 10 mg is indicated for the treatment of spasticity and skeletal muscle spasms related to various conditions, including:

• Multiple sclerosis

• Spinal cord injury and other spinal cord diseases

• Cerebrovascular accidents (stroke-related spasticity)

• Rheumatic disorders

• Neoplastic or degenerative brain diseases

• Other conditions associated with muscular rigidity and flexor spasms

Therapeutic Class

Centrally Acting Skeletal Muscle Relaxants

Pharmacology

Flexifen 10 mg acts primarily at the spinal level as an antispastic and muscle relaxant agent. Its therapeutic effect is mediated through stimulation of GABA_B receptors, which suppress the release of excitatory neurotransmitters such as glutamate and aspartate. This action inhibits both monosynaptic and polysynaptic reflexes responsible for muscle spasticity.

The drug may also exert mild central nervous system depressant effects at intraspinal sites. Flexifen 10 mg does not interfere with neuromuscular transmission and demonstrates antinociceptive (pain-relieving) properties, although the full clinical significance of this effect is not fully established.

Dosage & Administration

Flexifen 10 mg should be taken with a small amount of liquid, preferably during meals.

Adults:

• Administered in divided doses, usually three times daily

• Treatment should begin with a low dose and gradually increased

• Typical effective dose range: 30–80 mg per day

• Maximum recommended daily dose: 80 mg

Children:

• Initial dose: approximately 0.3 mg/kg/day in divided doses

• Dose may be increased cautiously at 1–2 week intervals

• Usual maintenance dose: 0.75–2 mg/kg/day

• For children over 10 years: maximum dose up to 2.5 mg/kg/day

The lowest effective dose should always be used to minimize adverse effects.

Drug Interactions

• Concomitant use with CNS depressants, alcohol, or opioids may enhance sedation and increase the risk of respiratory depression

• Combined use with antihypertensive drugs may lead to excessive lowering of blood pressure

• Tricyclic antidepressants may potentiate muscle-relaxant effects, causing pronounced hypotonia

• Use with levodopa and carbidopa in Parkinson’s disease patients has been associated with confusion, hallucinations, and agitation

• MAO inhibitors may increase CNS depressant effects

• Caution is advised with magnesium sulfate or neuromuscular blocking agents due to potential additive effects

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Flexifen 10 mg is contraindicated in patients with known hypersensitivity to any component of the formulation.

Side Effects

Common side effects include:

• Drowsiness

• Dizziness

• Weakness

• Fatigue

Less common but serious adverse reactions may include:

• Central nervous system effects such as confusion, hallucinations, seizures, and respiratory depression

• Cardiovascular effects including hypotension and palpitations

• Gastrointestinal disturbances such as nausea, constipation, and abdominal pain

• Genitourinary symptoms including urinary retention and frequency

• Other reactions such as rash, edema, weight gain, visual disturbances, and hepatic function abnormalities

Muscular hypotonia may occur but is usually reversible with dose adjustment.

Pregnancy & Lactation

Flexifen 10 mg is classified as Pregnancy Category B3. Its safety during pregnancy has not been fully established, and it crosses the placental barrier. Use during pregnancy should be considered only if the potential benefit justifies the possible risk. The drug is excreted in breast milk in very small amounts, and no adverse effects on nursing infants are generally expected.

Precautions & Warnings

• Dose reduction is recommended in patients with renal impairment or those on chronic hemodialysis

• Use with caution in patients with psychiatric disorders, epilepsy, cerebrovascular disease, or hepatic, renal, or respiratory impairment

• Abrupt discontinuation may lower the seizure threshold and precipitate seizures

• Regular monitoring of respiratory, cardiovascular, and hepatic function is advised in at-risk patients

Overdose Management

In cases of severe overdose, prompt gastric lavage and supportive treatment are recommended.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of the reach of children.