Tericin Injection 50 mg/vial contains Amphotericin B, a powerful broad-spectrum antifungal agent used for the treatment of serious and potentially life-threatening systemic fungal infections. It is commonly administered in hospital settings under strict medical supervision due to its potent activity and specific safety considerations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Tericin Injection is indicated for the treatment of severe fungal infections, including:

• Systemic candidiasis
• Cryptococcosis (including cryptococcal meningitis)
• Aspergillosis
• Histoplasmosis
• Blastomycosis
• Mucormycosis
• Visceral leishmaniasis (as per clinical guidance)

It is often used when other antifungal treatments are ineffective or not tolerated.

Mechanism of Action

Amphotericin B works by binding to ergosterol, a key component of fungal cell membranes. This action:

• Creates pores in the fungal cell membrane
• Causes leakage of essential intracellular components
• Leads to fungal cell death

This fungicidal effect makes it highly effective against a wide range of fungi.

Dosage and Administration

• Administered via intravenous infusion only under medical supervision
• Dosage depends on the type and severity of infection, as well as patient condition
• A test dose may be required before starting full therapy
• Infusion should be given slowly to reduce infusion-related reactions

Important: Dosage adjustments may be necessary in patients with kidney impairment or other comorbidities.

Benefits

• Broad-spectrum antifungal coverage
• Effective against life-threatening systemic infections
• Proven efficacy in resistant fungal cases
• Rapid fungicidal action

Side Effects

Common side effects include:

• Fever and chills (infusion-related reactions)
• Nausea and vomiting
• Headache
• Muscle or joint pain

Serious side effects may include:

• Nephrotoxicity (kidney damage)
• Electrolyte imbalance (low potassium or magnesium)
• Anemia
• Liver function abnormalities

Close monitoring is essential during treatment.

Precautions and Warnings

• Renal function and electrolyte levels must be monitored regularly
• Ensure adequate hydration before and during treatment
• Use cautiously in patients with kidney disease
• Monitor for infusion-related reactions
• Not recommended during pregnancy unless clearly necessary
• Inform healthcare providers about all medications being used

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Amphotericin B may interact with:

• Nephrotoxic drugs (e.g., aminoglycosides, cyclosporine)
• Corticosteroids (may worsen electrolyte imbalance)
• Digoxin (increased risk of toxicity due to low potassium)
• Diuretics

Careful monitoring and dose adjustments may be required.

Storage

• Store as per manufacturer’s instructions, typically below 25°C
• Protect from light
• Reconstituted solution should be used promptly or stored as directed
• Keep out of reach of children.