Flubex Capsule 250 mg contains Flucloxacillin Sodium, a penicillinase-resistant penicillin antibiotic. It is primarily used to treat a wide range of infections caused by penicillin-resistant Staphylococci and other susceptible gram-positive bacteria. Flubex is especially effective in managing skin, soft tissue, bone, and respiratory tract infections where beta-lactamase–producing organisms are suspected.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Flucloxacillin Sodium

• Strength: 250 mg per capsule

Therapeutic Class

• Beta-lactam antibiotic

• Penicillinase-resistant penicillin

Pharmacology

Flucloxacillin works by inhibiting bacterial cell wall synthesis. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, preventing the final cross-linking of peptidoglycan chains. This action weakens the bacterial cell wall, leading to cell lysis and death. Flucloxacillin is resistant to degradation by beta-lactamase enzymes produced by many staphylococcal strains, making it effective against penicillin-resistant bacteria.

After oral administration, flucloxacillin is moderately absorbed from the gastrointestinal tract, with better absorption when taken on an empty stomach. It is widely distributed in body tissues and fluids, particularly in skin, bone, and soft tissues.

Indications

Flubex Capsule 250 mg is indicated for the treatment of infections caused by flucloxacillin-sensitive organisms, including:

• Skin and soft tissue infections (boils, abscesses, cellulitis, impetigo)

• Bone and joint infections (osteomyelitis)

• Respiratory tract infections

• Ear, nose, and throat infections

• Infected wounds and burns

• Septicemia and other serious staphylococcal infections (as directed by a physician)

Dosage and Administration

• The usual adult dose is 250 mg to 500 mg every 6 hours, depending on the severity and type of infection.

• Capsules should be taken on an empty stomach, preferably 1 hour before or 2 hours after meals, for optimal absorption.

• Dosage in children and patients with renal impairment should be determined by a healthcare professional.

Contraindications

• Known hypersensitivity to flucloxacillin or other penicillin antibiotics

• History of flucloxacillin-associated jaundice or hepatic dysfunction

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use with caution in patients with liver disease or renal impairment

• Prolonged use may result in overgrowth of non-susceptible organisms

• Patients with a history of allergy to beta-lactam antibiotics should be closely monitored

Possible Side Effects

Common side effects may include:

• Nausea, vomiting, diarrhea

• Abdominal discomfort

• Skin rash or itching

Rare but serious adverse effects include cholestatic hepatitis, allergic reactions, and antibiotic-associated colitis.

Storage Conditions

• Store in a cool and dry place

• Protect from light and moisture

• Keep out of reach of children.