Fluconal Tablet 50 mg contains Fluconazole, a potent antifungal agent belonging to the triazole class. It is designed for the treatment and prevention of various fungal infections in adults and children. Fluconazole works by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. This disruption weakens the cell membrane, causing leakage of cellular contents and ultimately fungal cell death.

Fluconal Tablet 50 mg is widely used for treating infections caused by Candida species, Cryptococcus species, and other susceptible fungi. Its oral tablet form offers convenient dosing, excellent bioavailability, and consistent systemic absorption, making it effective for both localized and systemic fungal infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Fluconal Tablet 50 mg is indicated for the treatment and prevention of:

• Oropharyngeal and esophageal candidiasis

• Vaginal candidiasis (yeast infections)

• Systemic fungal infections caused by susceptible organisms

• Cryptococcal meningitis

• Prophylaxis in patients with immunocompromised conditions to prevent fungal infections

It should only be used when a fungal infection is confirmed or strongly suspected to prevent the development of resistance.

Mechanism of Action

• Inhibition of ergosterol synthesis: Fluconazole blocks the fungal cytochrome P450 enzyme 14α-demethylase, reducing ergosterol production, which is critical for maintaining fungal cell membrane integrity.

• Fungistatic and fungicidal effects: The drug halts fungal growth and, in some cases, leads to fungal cell death.

• Wide spectrum activity: Effective against Candida albicans, Candida glabrata, Candida tropicalis, Cryptococcus neoformans, and other susceptible fungi.

Dosage and Administration

Dosage depends on the type and severity of infection, as well as patient age and health status:

• Adults: 50 mg orally once daily for mild infections; dose may increase depending on infection severity

• Children: Dose is calculated based on body weight (typically 3–6 mg/kg/day)

• Tablets can be taken with or without food

• Duration of therapy varies: 1–2 weeks for mild infections and up to several weeks for systemic or recurrent infections

• Complete the full course even if symptoms improve early to prevent relapse and resistance

Benefits and Features

• Effective for a wide range of superficial and systemic fungal infections

• Convenient oral tablet form with excellent bioavailability

• Well-tolerated with minimal systemic absorption issues

• Can be used for both treatment and prophylaxis in high-risk patients

• Supports immune-compromised patients in preventing opportunistic fungal infections

Side Effects

Fluconal Tablet 50 mg is generally well tolerated. Possible side effects include:

• Gastrointestinal disturbances: nausea, vomiting, diarrhea, abdominal pain

• Headache or dizziness

• Skin rash or mild allergic reactions

• Rarely, liver enzyme elevation or hepatotoxicity

• Serious reactions are uncommon but require immediate medical attention

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use with caution in patients with liver or kidney impairment

• Monitor liver function during prolonged therapy

• Avoid use in patients with known hypersensitivity to fluconazole

• May interact with other medications metabolized via CYP450 enzymes, including anticoagulants and certain anti-arrhythmic drugs

• Not recommended during pregnancy unless prescribed by a healthcare professional

• Keep out of reach of children

Storage Conditions

Store Fluconal Tablet 50 mg in a cool, dry place below 30°C, protected from light and moisture. Keep tablets in their original packaging until use.

Fluconal Tablet 50 mg is an effective and reliable antifungal medication, suitable for the treatment and prevention of a variety of fungal infections, providing convenient oral dosing and proven clinical efficacy.