Folinex Tablet contains Folinic Acid (Leucovorin) 5 mg, an active form of folic acid that is used to support normal cell function and reduce the toxic effects of certain medications, especially in chemotherapy. Unlike regular folic acid, folinic acid does not require metabolic activation, allowing it to act quickly and effectively in the body.

It is commonly used in oncology, hematology, and in the management of folate deficiency when oral supplementation is required.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Uses

Folinex Tablet is indicated for:

• Prevention and treatment of folate deficiency
• Supportive therapy in methotrexate chemotherapy (low-dose regimens)
• Reduction of toxicity from antifolate drugs
• Adjunct therapy with 5-fluorouracil (5-FU) in cancer treatment
• Megaloblastic anemia due to folate deficiency (when oral therapy is appropriate)
• Nutritional support in patients with increased folate demand

Mechanism of Action

Folinic Acid works through multiple biological pathways:

• Bypasses inhibition of dihydrofolate reductase (DHFR) caused by methotrexate
• Restores folate-dependent DNA and RNA synthesis in normal cells
• Reduces toxic effects of antifolate chemotherapy agents
• Enhances anticancer activity of 5-FU by stabilizing drug binding to thymidylate synthase
• Supports healthy red blood cell formation and cellular repair

Dosage & Administration

• Usual dose: 5 mg once or as directed by physician
• Can be taken with or without food
• Dosage varies depending on medical condition and treatment protocol
• Must be taken strictly as prescribed in chemotherapy regimens
• Do not self-adjust dose without medical advice
• Regular monitoring may be required in long-term therapy

Side Effects

Folinex Tablet is generally well tolerated, but may include:

• Nausea
• Bloating or stomach discomfort
• Headache
• Allergic reactions (rare)
• Insomnia (rare)
• Mild gastrointestinal upset

Serious side effects are uncommon when used appropriately.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use only under medical supervision
• Do not confuse with folic acid dosage without physician advice
• Timing is important in patients receiving methotrexate
• Inform physician about all ongoing medications
• Use cautiously in patients with vitamin B12 deficiency (must be corrected first)
• Use during pregnancy only if prescribed

Storage

• Store below 25°C in a cool and dry place
• Protect from moisture and light
• Keep in original packaging
• Keep out of reach of children
• Do not use after expiry date.