Frenia 4 mg Tablet is an atypical antipsychotic used for the management of schizophrenia, bipolar disorder, and other psychotic conditions. It effectively treats both positive symptoms—such as hallucinations, delusions, thought disturbances, hostility, and suspiciousness—and negative symptoms, including blunted affect, social withdrawal, and poverty of speech. Additionally, Frenia 4 mg helps alleviate affective symptoms such as anxiety, depression, and guilt feelings. It is also used to maintain clinical improvement in patients who have responded to initial therapy and to manage manic episodes in bipolar disorder.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Frenia 4 mg is indicated for:

• Acute and chronic schizophrenic psychoses

• Other psychotic disorders with prominent positive or negative symptoms

• Relief of affective symptoms associated with schizophrenia

• Continuation therapy in patients who have shown initial treatment response

• Treatment of mania in bipolar disorder

Therapeutic Class

Atypical Neuroleptic Drugs

Pharmacology

Frenia 4 mg is a selective monoaminergic antagonist with high affinity for:

• Serotonin 5-HT2 receptors

• Dopamine D2 receptors

It also binds to alpha1 adrenergic receptors and, to a lesser extent, H1 histamine and alpha2 adrenergic receptors. It has no affinity for cholinergic receptors.

By antagonizing D2 receptors, Frenia improves positive symptoms with minimal motor depression. Its balanced serotonin-dopamine antagonism reduces the risk of extrapyramidal side effects and extends efficacy to negative and affective symptoms.

Dosage & Administration

Psychoses:

• Day 1: 2 mg in 1–2 divided doses

• Day 2: 4 mg in 1–2 divided doses

• Usual dose: 4–6 mg daily

• Maximum dose: 16 mg daily (only if benefits outweigh risks)

Elderly or patients with hepatic/renal impairment:

• Start at 1 mg daily in two divided doses, increase gradually in 1–2 mg increments

Mania:

• Initial: 2 mg once daily, increase by 1 mg/day if necessary

• Usual range: 1–6 mg/day

Schizophrenia:

• Start with 1 mg BID

• Increase by 1 mg BID over 2–3 days to a target of 3 mg BID

• Further adjustments should occur at intervals of at least 1 week, using small increments/decrements of 1–2 mg

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May antagonize the effects of levodopa and dopamine agonists

• Chronic use with carbamazepine reduces clearance

• Chronic use with clozapine may reduce clearance

• May enhance effects of certain antihypertensives

Contraindications

• Known hypersensitivity to Frenia or any component of the tablet

Side Effects

Common side effects:

• Insomnia, agitation, anxiety, headache

• Less common: drowsiness, impaired concentration, fatigue, blurred vision, constipation, nausea, vomiting, dyspepsia, abdominal pain

Other potential adverse effects:

• Hyperprolactinemia, urinary incontinence, tachycardia, hypertension, edema, rash, rhinitis

• Rare: cerebrovascular events, neutropenia, thrombocytopenia

Pregnancy & Lactation

• Pregnancy: Safety not established; animal studies show no teratogenicity but some prolactin- and CNS-mediated effects

• Lactation: Excreted in human breast milk; breastfeeding is not recommended

Precautions & Warnings

• Use with caution in patients with cardiovascular disease, renal or hepatic impairment, epilepsy, Parkinson’s disease, or elderly patients

• Monitor for tardive dyskinesia and discontinue if symptoms occur

• Caution advised during pregnancy

Overdose

Symptoms: drowsiness, sedation, tachycardia, hypotension, extrapyramidal effects. Severe cases may require anticholinergic therapy and close monitoring. No specific antidote exists.

Storage Conditions

Store in a cool, dry place, protected from light.