Gensulin M30 Injection 100 IU/ml is a premixed human insulin formulation containing 30% Regular Insulin Human (short-acting) and 70% Isophane Insulin Human (intermediate-acting). This balanced combination is designed to provide both rapid onset and prolonged glycemic control, making it an effective option for the management of diabetes mellitus. Gensulin M30 is administered by subcutaneous injection and is intended for use under medical supervision. 

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Regular Insulin Human: 30%

• Isophane Insulin Human (NPH): 70%

• Total Strength: 100 IU/ml

Therapeutic Class

• Antidiabetic agent

• Human insulin (premixed)

Indications

Gensulin M30 Injection is indicated for:

• Type 1 diabetes mellitus

• Type 2 diabetes mellitus where insulin therapy is required

• Patients requiring both basal and prandial insulin coverage in a single injection

It is particularly useful for patients who prefer a simplified insulin regimen with fewer daily injections.

Mechanism of Action

Gensulin M30 combines two types of insulin to mimic physiological insulin release. Regular Insulin Human provides a rapid onset of action, helping to control postprandial blood glucose levels after meals. Isophane Insulin Human has an intermediate duration of action, ensuring sustained basal insulin coverage between meals and overnight. Together, they facilitate glucose uptake into muscle and adipose tissue while suppressing hepatic glucose production, resulting in improved blood glucose control.

Dosage and Administration

• Gensulin M30 is administered by subcutaneous injection, usually once or twice daily, typically before meals.

• Dosage is individualized based on blood glucose monitoring, dietary habits, physical activity, and patient response.

• Injection sites should be rotated regularly to reduce the risk of lipodystrophy.

• The suspension should be gently rolled or inverted before use to ensure uniform mixing.

Administration must be guided by a healthcare professional experienced in insulin therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Elderly Patients: Careful dose titration is recommended due to increased risk of hypoglycemia.

• Renal or Hepatic Impairment: Dose adjustments may be required.

• Pregnancy and Lactation: Insulin is the preferred treatment for diabetes during pregnancy; use under medical supervision.

Side Effects

The most common side effect associated with insulin therapy is hypoglycemia, which may present as sweating, dizziness, tremor, hunger, or confusion. Other possible side effects include:

• Weight gain

• Injection site reactions such as redness or swelling

• Lipodystrophy with repeated injections at the same site

• Rare allergic reactions

Proper dose adjustment and patient education help minimize adverse effects.

Drug Interactions

Blood glucose levels may be affected by concomitant use of:

• Oral antidiabetic drugs

• Corticosteroids

• Beta-blockers

• Diuretics

Regular monitoring is advised when used with other medications.

Storage

• Store in a refrigerator at 2°C–8°C

• Do not freeze

• Protect from light

• Keep out of reach of children

Advantages of Gensulin M30 Injection

• Provides both rapid and intermediate insulin action

• Simplifies insulin therapy with premixed formulation

• Helps achieve stable glycemic control

• Suitable for long-term diabetes management