Gliclid MR Tablet 60 mg is a modified-release (MR) oral antidiabetic medication containing Gliclazide, a sulfonylurea class agent used for the management of type 2 diabetes mellitus. The MR formulation ensures gradual and sustained release of Gliclazide over 24 hours, providing stable and consistent blood glucose control with once-daily dosing.

Gliclid MR Tablet 60 mg is particularly suitable for patients whose diabetes cannot be effectively managed with diet and lifestyle changes alone. It works by stimulating the pancreatic beta cells to release insulin in response to blood glucose levels, thereby lowering fasting and postprandial glucose levels and helping reduce the risk of long-term diabetic complications such as neuropathy, nephropathy, and cardiovascular disorders.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Gliclid MR Tablet 60 mg is indicated for:

• Type 2 diabetes mellitus (non-insulin-dependent diabetes)

• Patients requiring long-acting glycemic control with once-daily medication

• Adjunctive therapy when diet, exercise, and lifestyle modifications are insufficient

• Can be used alone or in combination with other oral antidiabetic agents as prescribed

It is not suitable for type 1 diabetes or for the treatment of diabetic ketoacidosis.

Mechanism of Action

• Stimulates insulin secretion: Gliclazide binds to sulfonylurea receptors on pancreatic beta cells, causing closure of ATP-sensitive potassium channels.

• Membrane depolarization: This triggers calcium influx, stimulating insulin release.

• Modified-release advantage: The MR formulation allows slow, continuous drug release, maintaining stable blood glucose levels throughout the day.

• Glucose-dependent action: Insulin secretion occurs primarily when blood glucose is elevated, reducing the risk of hypoglycemia.

• Vascular protection: Gliclazide exhibits antioxidant and microvascular protective effects, helping prevent long-term diabetic complications.

Dosage and Administration

• Adults: 1 tablet (60 mg) once daily, preferably with breakfast to minimize hypoglycemia risk.

• Dose adjustments may be made based on blood glucose monitoring, up to the maximum recommended daily dose as advised by a physician.

• Swallow the tablet whole with water; do not crush or chew to maintain the modified-release properties.

• Continue with dietary control and regular exercise for optimal results.

• Regular blood glucose and HbA1c monitoring is recommended to assess treatment effectiveness.

Benefits and Features

• Provides long-acting, stable blood glucose control with once-daily dosing

• Reduces fasting and postprandial glucose levels effectively

• Glucose-dependent insulin release minimizes hypoglycemia risk

• Exhibits antioxidant and vascular protective properties

• Can be used alone or in combination therapy

• Supports long-term management of type 2 diabetes

Side Effects

Gliclid MR Tablet 60 mg is generally well tolerated. Possible side effects include:

• Hypoglycemia, especially if meals are skipped or delayed

• Mild gastrointestinal upset such as nausea, vomiting, or abdominal discomfort

• Rare allergic reactions like rash, itching, or photosensitivity

• Very rarely, hematologic abnormalities, such as thrombocytopenia

Patients should monitor blood glucose and consult a healthcare professional if adverse effects persist.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not suitable for type 1 diabetes or diabetic ketoacidosis

• Use with caution in elderly patients due to increased risk of hypoglycemia

• Alcohol may increase the risk of hypoglycemia and adverse reactions

• Inform your doctor about all medications to prevent interactions

• Maintain diet, exercise, and regular monitoring alongside therapy

Storage Conditions

Store Gliclid MR Tablet 60 mg in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep out of reach of children.

Gliclid MR Tablet 60 mg is a reliable and effective long-acting oral hypoglycemic agent that helps maintain stable blood glucose, support pancreatic insulin function, and reduce the risk of diabetic complications, making it ideal for adults seeking convenient once-daily glycemic control.