Glifo-M Tablet 5 mg + 500 mg is a combination oral antidiabetic medication containing Empagliflozin (5 mg) and Metformin Hydrochloride (500 mg). This combination is formulated for the effective management of type 2 diabetes mellitus by targeting high blood sugar through two complementary mechanisms.

• Empagliflozin, an SGLT2 inhibitor, works by reducing glucose reabsorption in the kidneys, promoting urinary excretion of excess glucose.

• Metformin Hydrochloride, a biguanide, reduces hepatic glucose production and improves insulin sensitivity, helping the body utilize glucose more efficiently.

Glifo-M combines these mechanisms to provide enhanced blood glucose control, supporting weight management, cardiovascular health, and metabolic balance. It is particularly suitable for adults whose blood sugar levels are not adequately controlled with monotherapy or lifestyle modifications alone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Glifo-M Tablet 5 mg + 500 mg is indicated for:

• Type 2 diabetes mellitus requiring improved glycemic control

• Patients needing dual-action therapy to manage fasting and postprandial blood glucose

• Adjunct therapy along with diet and exercise when lifestyle modifications alone are insufficient

• Adults at high cardiovascular risk, as Empagliflozin has proven cardiovascular protective effects

It is not intended for type 1 diabetes or diabetic ketoacidosis.

Mechanism of Action

• Empagliflozin: Blocks Sodium-Glucose Cotransporter-2 (SGLT2) in the kidney, increasing urinary glucose excretion and reducing plasma glucose.

• Metformin Hydrochloride: Suppresses hepatic gluconeogenesis, enhances peripheral insulin sensitivity, and reduces intestinal glucose absorption.

• Complementary effect: Targets both insulin-independent (Empagliflozin) and insulin-sensitive (Metformin) pathways for more effective blood glucose control.

• Additional benefits: Promotes weight reduction through caloric loss and supports cardiovascular and renal protection.

Dosage and Administration

• Adults: 1 tablet twice daily with meals, or as prescribed by a healthcare professional, to minimize gastrointestinal side effects.

• Dose adjustments may be required in patients with renal impairment.

• Monitoring: Regular checks of blood glucose, HbA1c, renal function, and electrolytes are recommended.

• Ensure adequate hydration, particularly due to Empagliflozin, to prevent dehydration.

• Maintain dietary measures, exercise, and lifestyle modifications for optimal results.

Benefits and Features

• Dual-action therapy for superior glycemic control

• Reduces fasting and postprandial blood sugar levels

• Supports weight management and reduces metabolic burden

• Provides cardiovascular and renal protective effects

• Convenient twice-daily dosing

• Can be used alone or in combination therapy

Side Effects

Glifo-M Tablet 5 mg + 500 mg is generally well tolerated. Possible side effects include:

• Gastrointestinal disturbances such as nausea, vomiting, or diarrhea (mainly due to Metformin)

• Increased urination and mild dehydration due to Empagliflozin

• Genital or urinary tract infections, more common in women

• Rare hypoglycemia, particularly if combined with other insulin secretagogues

• Rare allergic reactions such as rash or itching

Patients should consult a healthcare provider if adverse effects persist or are severe.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not suitable for type 1 diabetes or diabetic ketoacidosis

• Use caution in patients with renal impairment, dehydration, or elderly patients

• Maintain adequate fluid intake to prevent hypotension and dehydration

• Inform healthcare providers about all medications to avoid drug interactions

• Regular monitoring of blood glucose, renal function, and electrolytes is essential

Storage Conditions

Store Glifo-M Tablet 5 mg + 500 mg in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.

Glifo-M Tablet 5 mg + 500 mg is an effective combination therapy that provides comprehensive blood glucose control, weight management, and cardiovascular protection, making it ideal for adults with type 2 diabetes seeking dual-action, convenient antidiabetic therapy.