Glifo-M XR Tablet 25 mg+1000 mg is a combination oral antidiabetic medication formulated with Empagliflozin 25 mg and Metformin Hydrochloride 1000 mg in an extended-release (XR) form. It is indicated for the treatment of type 2 diabetes mellitus in adults, particularly in patients who require dual therapy to achieve optimal glycemic control.

This advanced formulation combines two complementary agents that target different pathways involved in glucose regulation. When used alongside a balanced diet and regular physical activity, Glifo-M XR helps maintain stable blood sugar levels and reduces the risk of diabetes-related complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each extended-release tablet contains:

• Empagliflozin 25 mg

• Metformin Hydrochloride 1000 mg (Extended Release)

Mechanism of Action

Empagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by blocking glucose reabsorption in the kidneys, leading to increased urinary glucose excretion. This insulin-independent mechanism effectively lowers blood glucose levels and may also contribute to modest weight reduction.

Metformin Hydrochloride belongs to the biguanide class. It reduces hepatic glucose production, improves insulin sensitivity, and enhances peripheral glucose uptake. The extended-release formulation ensures gradual release of Metformin, providing sustained glucose control while minimizing gastrointestinal side effects.

Together, these two agents offer comprehensive glycemic management by addressing both renal glucose handling and insulin resistance.

Indications

Glifo-M XR Tablet 25 mg+1000 mg is indicated for:

• Management of type 2 diabetes mellitus in adults

• Patients inadequately controlled on Metformin alone

• Individuals requiring combination therapy for better glycemic control

• Reducing the risk of diabetes-related cardiovascular complications, as advised by a healthcare professional

Benefits

• Dual mechanism of action for enhanced blood glucose control

• Effective reduction of fasting and postprandial glucose levels

• Extended-release formulation improves tolerability

• May support weight management

• Convenient dosing regimen for improved patient adherence

Dosage and Administration

The dosage should be determined by a registered physician based on individual patient needs, kidney function, and current treatment regimen. It is usually taken once daily with meals to reduce gastrointestinal discomfort. The tablet should be swallowed whole with water and should not be crushed, broken, or chewed.

Precautions

• Not recommended for patients with severe renal impairment

• Regular monitoring of renal function is advised

• Risk of lactic acidosis with Metformin, though rare

• Maintain adequate hydration during treatment

• Inform your doctor about any history of liver, kidney, or heart disease

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Nausea or abdominal discomfort

• Increased urination

• Urinary tract infections

• Genital fungal infections

• Headache or dizziness

Seek medical advice if symptoms persist or worsen.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Glifo-M XR Tablet 25 mg+1000 mg offers a reliable and effective combination therapy for adults with type 2 diabetes, helping achieve better glycemic control under proper medical supervision.