Hepaclin Powder 3 gm/sachet is a hepatoprotective and ammonia-lowering formulation containing L-Ornithine L-Aspartate (LOLA). This combination of amino acids is designed to support liver function, detoxification, and metabolic balance in patients with liver disorders. Hepaclin acts by enhancing the urea cycle and glutamine synthesis, facilitating the removal of excess ammonia from the body, which is particularly beneficial in conditions such as hepatic encephalopathy, cirrhosis, and other liver dysfunctions. The sachet form allows for easy dissolution in water, juice, or other liquids, providing convenient oral administration.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Hepaclin Powder 3 gm/sachet is indicated for:

• Hepatic encephalopathy associated with chronic liver disease

• Management of hyperammonemia due to liver dysfunction

• Supportive therapy in cirrhosis and chronic liver disorders

• Improvement of general liver metabolism and detoxification

• Adjunctive treatment in acute or chronic liver disease to reduce ammonia-induced neurological symptoms

Hepaclin is often used alongside dietary management and other medications to improve cognitive function, reduce fatigue, and restore metabolic balance in liver-compromised patients.

Therapeutic Class

• Hepatoprotective / Amino Acid Supplement

• Ammonia-Lowering Agent

Pharmacology

L-Ornithine L-Aspartate is a combination of the amino acids L-ornithine and L-aspartate, which work synergistically to lower elevated blood ammonia levels.

• Mechanism of action:

  • Ornithine acts as a substrate for the urea cycle, facilitating the conversion of ammonia into urea for renal excretion.

  • Aspartate contributes to glutamine synthesis, another pathway for ammonia detoxification.

This dual mechanism enhances hepatic detoxification, reduces neurotoxicity caused by hyperammonemia, and supports the overall metabolic function of the liver.

Dosage and Administration

• Recommended dose: 1–2 sachets (3–6 gm) 2–3 times daily, depending on the severity of hyperammonemia or liver disease

• Dissolve the contents of the sachet in water, juice, or milk and consume immediately

• Can be administered orally or via nasogastric tube in patients who are unable to take medications orally

Dosage may be adjusted according to patient response, age, and liver function status. Long-term use should be monitored by a healthcare professional.

Drug Interactions

• No major drug interactions have been reported

• Use caution with concurrent diuretics or medications affecting renal or hepatic function

• Monitor liver function when co-administered with hepatotoxic drugs

Contraindications

• Known hypersensitivity to L-Ornithine, L-Aspartate, or any component of the formulation

• Severe renal failure without close monitoring

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Hepaclin is generally well-tolerated. Possible side effects include:

• Gastrointestinal discomfort such as nausea, vomiting, or diarrhea

• Mild headache or dizziness in sensitive individuals

• Rare allergic reactions, including rash or pruritus

Pregnancy and Lactation

• Limited data on use in pregnancy; should be used only if clearly needed

• Likely safe during lactation, but consult a healthcare professional before use

Precautions and Warnings

• Monitor ammonia levels and liver function during treatment

• Not a substitute for dietary or medical management of liver disease

• Ensure adequate hydration to support renal excretion of urea

Storage Conditions

• Store at room temperature below 30°C

• Keep in a dry, protected place away from direct sunlight

• Keep out of reach of children.