Herlyn Tablet 40 mg contains Neratinib Maleate, an oral targeted anticancer medicine used in the treatment of HER2-positive breast cancer. It belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs), which work by blocking specific signals responsible for the growth and survival of cancer cells. Herlyn is mainly used as extended adjuvant therapy after initial treatment with trastuzumab-based therapy to reduce the risk of cancer recurrence.

Neratinib is an irreversible inhibitor of HER1, HER2, and HER4 receptors, making it effective in controlling HER2-driven tumor progression.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Neratinib Maleate equivalent to Neratinib 40 mg

Mechanism of Action

Neratinib works by irreversibly binding to the intracellular tyrosine kinase domain of HER2 and related epidermal growth factor receptors. This prevents phosphorylation and downstream signaling pathways that promote cancer cell proliferation, survival, and metastasis. By blocking these pathways, it helps slow tumor growth and reduce the likelihood of disease recurrence in HER2-positive breast cancer patients.

Indications

Herlyn Tablet 40 mg is indicated for:

• Extended adjuvant treatment of early-stage HER2-positive breast cancer
• Patients who have completed trastuzumab-based therapy
• Hormone receptor-positive, HER2-positive breast cancer (in combination with endocrine therapy, as prescribed)
• Reduction of recurrence risk in high-risk breast cancer patients

Dosage and Administration

• To be taken orally as prescribed by an oncologist
• Usually taken once daily with food
• Tablets should be swallowed whole with water
• Treatment duration is typically up to 1 year in adjuvant settings
• Antidiarrheal prophylaxis may be required during initial therapy
• Dose adjustments may be necessary based on tolerance

Contraindications

Herlyn Tablet should not be used in:

• Known hypersensitivity to Neratinib or any excipients
• Severe hepatic impairment without strict medical supervision
• Pregnancy and breastfeeding unless clearly advised by a specialist

Side Effects

Common side effects may include:

• Diarrhea (very common, may be severe)
• Nausea and vomiting
• Abdominal pain
• Fatigue
• Decreased appetite
• Mouth ulcers
• Liver enzyme elevation

Serious side effects may include:

• Severe dehydration due to diarrhea
• Hepatotoxicity
• Skin rash

Precautions

• Antidiarrheal prophylaxis is strongly recommended during initial treatment
• Liver function tests should be monitored regularly
• Maintain adequate hydration during therapy
• Use cautiously in patients with pre-existing liver disease
• Avoid pregnancy during treatment and for a period after completion
• Should only be used under specialist oncology supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Herlyn Tablet may interact with:

• Strong CYP3A4 inhibitors or inducers (may alter drug levels)
• Proton pump inhibitors (may reduce absorption)
• Grapefruit products (may increase toxicity risk)
• Other hepatotoxic medications

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.