Hypnofast 15 mg/3 ml is a benzodiazepine-based sedative and hypnotic indicated for the short-term management of insomnia and sedation prior to surgical or diagnostic procedures. It acts on the central nervous system (CNS) to enhance the inhibitory effect of GABA, producing sedation, muscle relaxation, and anxiolysis.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

• Short-term treatment of insomnia

• Premedication sedation for surgical or diagnostic procedures, including endoscopic and cardiovascular procedures

• Induction of anesthesia in adults and children

Note: Use only under the guidance of a registered healthcare professional.

Therapeutic Class

• Benzodiazepine hypnotics

• Benzodiazepine sedatives

Pharmacology

Hypnofast binds to benzodiazepine receptors located on postsynaptic GABA neurons in the CNS, including the limbic system and reticular formation. By enhancing GABA’s inhibitory effect, Hypnofast increases chloride ion influx, leading to neuronal hyperpolarization. This stabilizes neurons, reduces excitability, and produces sedation, muscle relaxation, and anxiolytic effects. Its action is primarily mediated through the GABA-A receptor complex.

Dosage & Administration

Oral Use:

• Adults: 7.5–15 mg daily for insomnia

• Elderly: 7.5 mg daily

• Premedication: 7.5–15 mg orally, 30–60 minutes before procedure

Intravenous (IV) Use:

• Endoscopic/Cardiovascular procedures:

  • Adults: 2.5 mg initially

  • Elderly/debilitated: 1–1.5 mg initially

• Induction of anesthesia: 10–15 mg (0.07–0.1 mg/kg)

Intramuscular (IM) Use:

• Adults: 0.07–0.1 mg/kg

• Children: 0.15–0.20 mg/kg

• Elderly/debilitated: 0.025–0.05 mg/kg

Rectal Use (children): 0.35–0.45 mg/kg, 20–30 min before anesthesia

Maximum duration: Short-term treatment; typically ≤2 weeks

Interactions

Hypnofast may enhance CNS depression when used with:

• Neuroleptics, antidepressants, sleep-inducing drugs

• Analgesics, anesthetics, anxiolytics

• Antiepileptics, sedative antihistamines

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Severe respiratory insufficiency

• Severe hepatic insufficiency

• Myasthenia gravis

• Sleep apnea syndrome

• Known hypersensitivity to benzodiazepines

Side Effects

• Daytime drowsiness, confusion, fatigue, headache, muscle weakness

• IV/IM administration: respiratory depression, apnea, BP and pulse fluctuations

• Rare: allergic reactions, paradoxical excitation

Pregnancy & Lactation

• Avoid unless no safer alternative; may affect fetus

• Excreted in breast milk; should not be used by nursing mothers

Precautions & Warnings

• IV administration should be very slow

• Use with caution in hepatic/renal impairment, elderly, debilitated, or epileptic patients

• May potentiate effects of other CNS depressants

Overdose

• Severe overdose may cause coma, areflexia, respiratory depression, apnea

• Treatment: supportive care and benzodiazepine antagonist (flumazenil)

Mode of Action

Hypnofast potentiates GABA-A receptor activity, increasing chloride channel opening frequency, resulting in:

• Sedation

• Muscle relaxation

• Sleep induction

• Anesthesia and amnesia

Its receptors are mainly located in the CNS but also present in other tissues like skeletal muscle.

Storage Conditions

• Protect from light and moisture

• Store in a cool, dry place

• Keep out of reach of children