Hypnofast 5 mg/ml is a benzodiazepine-based sedative and hypnotic indicated for the short-term treatment of insomnia and for premedication before surgical or diagnostic procedures. Containing a highly potent benzodiazepine, Hypnofast acts on the central nervous system to produce sedation, reduce anxiety, induce muscle relaxation, and facilitate sleep. Its multiple routes of administration—including oral, intravenous, intramuscular, and rectal—make it versatile for both acute hospital use and controlled outpatient management.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Hypnofast 5 mg/ml is indicated for:

• Short-term management of insomnia in adults

• Sedation and anxiolysis prior to surgical or diagnostic procedures

• Preoperative sedation in children via rectal or intramuscular administration

• Sedation during endoscopic or cardiovascular procedures

• Induction of anesthesia in adults and children

It is particularly useful when rapid onset and reliable sedation are required in a controlled medical setting.

Therapeutic Class

• Benzodiazepine Hypnotic

• Benzodiazepine Sedative

Pharmacology

Hypnofast 5 mg/ml binds to benzodiazepine receptors on GABA-A neurons in the CNS, including the limbic system and reticular formation. By enhancing the inhibitory effect of GABA (gamma-aminobutyric acid), Hypnofast increases neuronal membrane permeability to chloride ions, causing hyperpolarization and reducing neuronal excitability. This mechanism results in:

• Sedation and hypnotic effects

• Muscle relaxation

• Anxiolysis

• Amnesia and anticonvulsant properties

Benzodiazepine receptors are stereospecific and modulate CNS excitability without directly acting on other neurotransmitter systems.

Dosage and Administration

Short-term insomnia:

• Adults: 7.5–15 mg orally per day

• Elderly: 7.5 mg orally per day

Premedication (before procedures):

• Adults: 7.5–15 mg orally 30–60 minutes prior

• Children (rectal): 0.35–0.45 mg/kg 20–30 minutes before anesthesia

Intravenous administration:

• Endoscopic/Cardiovascular procedures: Adults 2.5 mg; Elderly 1–1.5 mg

• Induction of anesthesia: Adults 10–15 mg IV; Children 0.15–0.20 mg/kg IM; Elderly 0.025–0.05 mg/kg IM

Important administration notes:

• IV doses should be administered slowly under close monitoring

• Rectal administration is reserved for children when oral or IV routes are not suitable

Drug Interactions

• Enhanced sedative effects with neuroleptics, antidepressants, analgesics, anesthetics, anxiolytics, antiepileptics, and sedative antihistamines

• Additive CNS depression possible when used with alcohol or other sedatives

Contraindications

• Severe respiratory insufficiency

• Severe hepatic impairment

• Myasthenia gravis

• Sleep apnea syndrome

• Hypersensitivity to benzodiazepines

Side Effects

Common side effects:

• Drowsiness, confusion, fatigue, headache, and muscle weakness (usually resolve with continued use)

• IV or IM administration may cause respiratory depression, apnea, and fluctuations in blood pressure or pulse

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

• Avoid during pregnancy unless no safer alternatives are available

• Excreted in breast milk; not recommended for nursing mothers

Precautions and Warnings

• Monitor respiratory and cardiovascular function during IV administration

• Use with caution in elderly or debilitated patients

• Dose adjustment may be necessary in hepatic impairment

• Hypnofast IV must be administered slowly to prevent adverse effects

Overdose

• May result in coma, areflexia, cardiorespiratory depression, and apnea

• Flumazenil, a benzodiazepine antagonist, can reverse overdosage effects

• Supportive care may include respiratory and cardiovascular monitoring

Storage Conditions

• Protect from light and moisture

• Store in a cool, dry place

• Keep out of reach of children