Trexall Tablet 2.5 mg contains Methotrexate, an antimetabolite and immunosuppressant medicine used for the treatment of autoimmune diseases, inflammatory disorders, and certain types of cancer. It works by slowing down abnormal cell growth and reducing overactivity of the immune system.

This low-dose formulation is commonly used in long-term management of conditions such as rheumatoid arthritis and psoriasis, under strict medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Methotrexate 2.5 mg

Available as an oral tablet.

Indications

Trexall Tablet 2.5 mg is indicated for:

• Rheumatoid arthritis (moderate to severe)
• Psoriatic arthritis
• Severe psoriasis
• Juvenile idiopathic arthritis (in selected cases)
• Certain cancers (as part of combination chemotherapy)
• Other autoimmune or inflammatory conditions as prescribed by a physician

Mechanism of Action

Methotrexate works by inhibiting the enzyme dihydrofolate reductase (DHFR), which is essential for DNA synthesis and cell replication. By blocking this enzyme, it reduces the growth of rapidly dividing cells, including immune cells responsible for inflammation.

In autoimmune diseases, this helps decrease swelling, pain, and joint damage over time.

Dosage and Administration

Trexall Tablet should be taken exactly as prescribed by a healthcare professional.

General guidelines:

• Usually taken once weekly (not daily in autoimmune conditions)
• Dose is individualized based on disease severity and response
• Can be taken with or without food
• Swallow whole with water

Folic acid supplementation may be recommended to reduce side effects.

Benefits of Trexall Tablet

• Reduces joint pain and swelling in rheumatoid arthritis
• Slows progression of autoimmune diseases
• Improves mobility and quality of life
• Helps control severe psoriasis symptoms
• Effective long-term disease management option

Possible Side Effects

Common side effects include:

• Nausea and vomiting
• Mouth ulcers
• Fatigue
• Loss of appetite
• Mild hair thinning
• Stomach discomfort

Serious side effects may include:

• Liver toxicity
• Bone marrow suppression (low blood cells)
• Increased risk of infections
• Lung inflammation (rare but serious)

Precautions and Warnings

• Strictly avoid use during pregnancy (can cause birth defects)
• Regular blood tests (CBC, liver and kidney function) are essential
• Avoid alcohol to reduce risk of liver damage
• Use cautiously in liver or kidney disease
• Do not take daily unless specifically prescribed for cancer treatment
• Inform the doctor about all other medications being used

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store below 25°C
• Protect from moisture and light
• Keep out of reach of children
• Use only under medical prescription

Conclusion

Trexall Tablet 2.5 mg (Methotrexate) is a widely used low-dose immunosuppressant for managing rheumatoid arthritis, psoriasis, and other inflammatory conditions. By controlling immune system overactivity and reducing inflammation, it helps improve long-term disease outcomes. Safe use requires regular monitoring and strict adherence to medical guidance.