Hyronate Injection 20 mg/2 ml contains Sodium Hyaluronate, a naturally occurring glycosaminoglycan widely used in orthopedic and joint health treatments. It is primarily indicated for viscosupplementation in osteoarthritis of the knee and other joints, helping to restore the lubricating and shock-absorbing properties of synovial fluid. By improving joint function and reducing pain, Hyronate supports mobility and enhances quality of life in patients with degenerative joint conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

• Osteoarthritis of the knee: Relief of pain and improvement of joint mobility

• Joint lubrication in patients with reduced synovial fluid

• Adjunct therapy for chronic degenerative joint disorders

• Prevention of cartilage degeneration and support of joint health

Note: Use only under the supervision of a registered healthcare professional.

Therapeutic Class

• Viscosupplementation agents

• Glycosaminoglycan preparations

Pharmacology

Sodium Hyaluronate is a high molecular weight polysaccharide found in synovial fluid, cartilage, and connective tissues. It functions as a viscoelastic lubricant and shock absorber, supporting joint movement and reducing mechanical stress on cartilage.

When injected intra-articularly, Hyronate:

• Restores the viscosity and elasticity of synovial fluid

• Protects cartilage from mechanical damage

• Reduces pain and inflammation through mechanical and biological effects

• Stimulates endogenous production of hyaluronic acid in the joint

This action improves joint function, decreases stiffness, and may delay progression of osteoarthritis.

Dosage & Administration

• Adults: Typically, 20 mg/2 ml per joint, administered intra-articularly once weekly for 3–5 weeks, depending on the severity of the condition and physician recommendation.

• Technique: Use strict aseptic technique to prevent infection. Inject directly into the joint space, ensuring correct placement using palpation or imaging guidance if necessary.

• Frequency: A single course of injections is often repeated after 6–12 months if required.

Note: Not intended for intravenous or intramuscular use; strictly for intra-articular injection.

Interactions

• No clinically significant drug interactions reported.

• Caution advised when used alongside other intra-articular agents or anticoagulants.

Contraindications

• Known hypersensitivity to sodium hyaluronate or any component of the formulation

• Infection or skin lesions at the injection site

• Severe joint deformities where injection may not be feasible

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Hyronate is generally well tolerated. Some patients may experience:

• Temporary pain, swelling, or warmth at the injection site

• Mild erythema or effusion in the joint

• Rare allergic reactions

Most adverse effects are transient and resolve without intervention.

Pregnancy & Lactation

• Limited data available; should be used during pregnancy or lactation only if clearly needed and under medical supervision.

Precautions & Warnings

• Administer using aseptic technique to avoid infection.

• Monitor for joint infection, acute synovitis, or pseudoseptic reactions.

• Use with caution in patients with bleeding disorders or on anticoagulants.

Overdose

• No specific overdose data available; excessive intra-articular injection may lead to joint swelling or discomfort, managed by rest and symptomatic treatment.

Mode of Action

Sodium Hyaluronate functions as a viscoelastic supplement for synovial fluid. It restores joint lubrication and shock absorption, reduces mechanical stress on cartilage, and improves joint mobility. By replenishing hyaluronic acid levels, it provides both symptomatic relief and potential structural support in osteoarthritis.

Storage Conditions

• Store in a cool, dry place at 2–25°C

• Protect from light and freezing

• Keep out of reach of children.