Ifomes Injection 400 mg/4 ml contains Mesna, a uroprotective agent used to prevent hemorrhagic cystitis (bleeding and inflammation of the bladder) caused by certain chemotherapy drugs such as ifosfamide and cyclophosphamide. Mesna does not have anticancer activity itself but plays a crucial supportive role in reducing the toxic effects of chemotherapy on the urinary tract.

This injection is administered in hospital settings under medical supervision, usually alongside chemotherapy regimens.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 4 ml ampoule contains:

• Mesna 400 mg

Mechanism of Action

Mesna works by binding to and detoxifying harmful metabolites (such as acrolein) produced during the metabolism of certain chemotherapy agents. These toxic metabolites can damage the bladder lining. Mesna neutralizes them in the urine, forming non-toxic compounds that are safely excreted, thereby protecting the urinary tract from injury.

Indications

Ifomes Injection 400 mg/4 ml is indicated for:

• Prevention of hemorrhagic cystitis caused by ifosfamide therapy
• Prevention of urinary toxicity associated with cyclophosphamide (high-dose therapy)
• Supportive care in patients undergoing chemotherapy with urotoxic agents

Dosage and Administration

• Administered intravenously under medical supervision
• Dosage is calculated based on the dose of the chemotherapy agent
• Given before, during, and after chemotherapy as part of a protective regimen
• Adequate hydration is essential during treatment
• Urine output and renal function should be monitored

Contraindications

Ifomes Injection should not be used in:

• Known hypersensitivity to Mesna or related compounds
• Severe allergic reactions to thiol-containing drugs

Side Effects

Possible side effects include:

• Nausea and vomiting
• Headache
• Flushing
• Fever
• Injection site reactions
• Rare allergic reactions such as rash or bronchospasm

Precautions

• Ensure adequate hydration to enhance urinary protection
• Monitor for signs of allergic reactions
• Does not prevent other chemotherapy-related toxicities
• Use cautiously in patients with autoimmune disorders
• Administer only under trained healthcare supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Ifomes Injection may interact with:

• Chemotherapy agents (used in combination, not a harmful interaction)
• No significant interactions with most other drugs, but clinical monitoring is advised

Storage Conditions

• Store below 25°C in a cool, dry place
• Protect from light
• Do not freeze
• Keep out of reach of children.