Nevirax Tablet 150 mg+100 mg is a combination antiviral medication containing Nirmatrelvir and Ritonavir. It is specifically designed for the treatment of COVID-19 in patients at risk of developing severe illness. Nirmatrelvir inhibits a key viral enzyme (protease) required for SARS-CoV-2 replication, while Ritonavir enhances the effectiveness of Nirmatrelvir by slowing its metabolism. Together, they help reduce viral load and improve patient outcomes when administered early in the course of infection.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Nevirax Tablet 150 mg+100 mg is indicated for:

• Treatment of mild to moderate COVID-19 in adults and adolescents at high risk of progression to severe disease
• Reducing the risk of hospitalization and severe COVID-19 outcomes
• Early intervention in patients with underlying conditions such as diabetes, obesity, or cardiovascular disease

Mechanism of Action

• Nirmatrelvir: Inhibits SARS-CoV-2 main protease (Mpro), preventing viral replication.
• Ritonavir: Slows the breakdown of Nirmatrelvir in the body, enhancing its antiviral effect.

This combination ensures rapid suppression of viral replication, aiding recovery and reducing the risk of severe disease.

Dosage and Administration

• The standard dose is 150 mg Nirmatrelvir + 100 mg Ritonavir, taken orally twice daily for 5 days
• Tablets should be taken together with or without food
• Start treatment as soon as possible after diagnosis of COVID-19
• Adjustments may be required in patients with moderate kidney impairment; not recommended in severe kidney or liver impairment

Follow the prescribing physician’s instructions carefully to ensure safety and efficacy.

Benefits

• Rapid antiviral action against SARS-CoV-2
• Reduces the risk of hospitalization and severe COVID-19
• Convenient oral therapy
• Suitable for early outpatient management
• Enhances recovery and reduces disease progression

Possible Side Effects

Common side effects include:

• Altered taste (dysgeusia)
• Diarrhea
• High blood pressure (mild)
• Muscle aches
• Headache

Serious side effects (rare):

• Severe allergic reactions
• Liver function abnormalities
• Drug interactions leading to heart rhythm disturbances

Seek immediate medical attention if severe symptoms occur.

Precautions and Warnings

• Use only under medical supervision
• Not a substitute for vaccination or other COVID-19 preventive measures
• Inform your physician about all medications to prevent interactions
• Caution in patients with liver or kidney impairment
• Avoid use during pregnancy and breastfeeding unless prescribed

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Nevirax may interact with medications including:

• Antiarrhythmics
• Anticoagulants
• Certain anticonvulsants
• Statins and other cardiovascular drugs
• Immunosuppressants

Always inform your healthcare provider about all medications and supplements being taken.

Storage

• Store below 30°C in a dry place
• Keep tablets in their original blister pack until use
• Protect from moisture and light
• Keep out of reach of children.