Insul Glargine Injection 100 IU/ml contains insulin glargine, a long-acting basal insulin analogue used for the management of diabetes mellitus. It provides a steady and continuous release of insulin, helping to maintain blood glucose control for up to 24 hours with minimal peaks, making it suitable for once-daily administration.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Insulin Glargine 100 IU/ml

Mechanism of Action

Insulin glargine is a long-acting insulin analogue that works by facilitating the uptake of glucose into peripheral tissues and suppressing hepatic glucose production. After subcutaneous injection, it forms microprecipitates at the injection site, allowing a slow and consistent release of insulin over an extended period. This provides stable basal insulin coverage throughout the day and night.

Indications

Insul Glargine Injection is indicated for:

• Type 1 diabetes mellitus as basal insulin therapy
• Type 2 diabetes mellitus when oral antidiabetic agents or other insulins are insufficient
• Basal insulin replacement in combination with rapid-acting or short-acting insulin
• Management of hyperglycemia in both outpatient and inpatient settings

Dosage and Administration

• Administered via subcutaneous injection only
• Usually given once daily at the same time each day
• Dosage is individualized based on blood glucose levels, dietary habits, and clinical response
• Common injection sites include abdomen, thigh, or upper arm
• Rotate injection sites regularly to avoid lipodystrophy

Advantages

• Provides steady, peakless insulin release
• Once-daily dosing improves patient compliance
• Reduces risk of nocturnal hypoglycemia compared to some intermediate-acting insulins
• Can be combined with mealtime insulin for comprehensive glucose control

Possible Side Effects

Common side effects include:

• Hypoglycemia (low blood sugar)
• Injection site reactions (redness, swelling, or pain)
• Weight gain
• Lipodystrophy at injection sites

Less common but serious effects:

• Severe hypoglycemia leading to confusion, seizures, or unconsciousness
• Allergic reactions
• Hypokalemia (low potassium levels)

Precautions

• Regular blood glucose monitoring is essential
• Do not mix with other insulin formulations in the same syringe
• Dose adjustment may be required during illness, stress, or dietary changes
• Use cautiously in patients with kidney or liver impairment
• Alcohol may increase risk of hypoglycemia

Contraindications

• Hypoglycemia episodes
• Known hypersensitivity to insulin glargine or any component of the formulation

Drug Interactions

• Corticosteroids may increase blood glucose levels
• Beta-blockers may mask hypoglycemia symptoms
• Oral antidiabetic agents may enhance insulin effect
• Diuretics and thyroid medications may affect glycemic control

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a refrigerator at 2°C to 8°C
• Do not freeze
• Protect from direct heat and sunlight
• Once in use, may be kept at room temperature for a limited period as directed

Important Notes

Insul Glargine Injection 100 IU/ml is a long-acting basal insulin designed to provide stable and continuous blood glucose control. It is an essential component of modern diabetes management and should be used under proper medical supervision with regular monitoring.