Glipxen-M Tablet 2.5 mg+500 mg is a combination antidiabetic medicine containing Linagliptin and Metformin Hydrochloride. It is used in the management of type 2 diabetes mellitus when blood sugar levels are not adequately controlled with diet, exercise, or single-agent therapy. This combination helps improve both fasting and postprandial glucose levels through complementary mechanisms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Linagliptin 2.5 mg
• Metformin Hydrochloride 500 mg

Mechanism of Action

• Linagliptin inhibits the DPP-4 enzyme, increasing incretin hormones (GLP-1 and GIP), which enhance insulin secretion and reduce glucagon release in a glucose-dependent manner.
• Metformin decreases hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues.

Together, these actions provide effective glycemic control with a low risk of hypoglycemia when used appropriately.

Indications

Glipxen-M Tablet 2.5 mg+500 mg is indicated for:

• Type 2 diabetes mellitus in adults
• Patients inadequately controlled on metformin alone
• Combination therapy to improve overall glycemic control
• Management of fasting and post-meal blood glucose levels

Dosage and Administration

• To be taken orally as prescribed by a physician
• Usually taken once or twice daily with meals to reduce gastrointestinal discomfort
• Swallow whole with water; do not crush or chew
• Dosage should be individualized based on glycemic response
• Regular monitoring of blood glucose and HbA1c is recommended

Contraindications

Glipxen-M Tablet should not be used in:

• Type 1 diabetes mellitus
• Diabetic ketoacidosis
• Severe renal impairment
• Metabolic acidosis or lactic acidosis
• Known hypersensitivity to Linagliptin or Metformin

Side Effects

Possible side effects include:

• Nausea, vomiting, or diarrhea
• Abdominal discomfort or bloating
• Headache
• Upper respiratory tract infections
• Hypoglycemia (especially with insulin or sulfonylureas)
• Rare but serious risk of lactic acidosis (due to Metformin)

Precautions

• Monitor kidney function before and during treatment
• Avoid excessive alcohol consumption
• Use cautiously in elderly patients
• May need temporary discontinuation before surgery or contrast imaging
• Continue diet and exercise for optimal results

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Glipxen-M Tablet may interact with:

• Insulin and sulfonylureas (increased risk of hypoglycemia)
• Alcohol (increased risk of lactic acidosis)
• Diuretics and antihypertensive drugs
• Rifampicin (may reduce Linagliptin effectiveness)

Storage Conditions

• Store below 30°C in a dry place
• Protect from moisture and direct sunlight
• Keep out of reach of children.