Safina Tablet 100 mg contains Safinamide Mesylate, a modern adjunct therapy used in the management of Parkinson’s disease. It is primarily prescribed as an add-on treatment to levodopa-based therapy in patients experiencing “off” episodes, where motor symptoms temporarily worsen. Safinamide helps improve motor control, reduce symptom fluctuations, and enhance quality of life in patients with Parkinson’s disease.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Safinamide Mesylate 100 mg

Indications

Safina Tablet is indicated for:

• Parkinson’s disease as adjunct therapy to levodopa/carbidopa
• Management of motor fluctuations (wearing-off effects)
• Improvement of tremor, rigidity, and bradykinesia in advanced Parkinson’s disease
• Patients requiring better symptom control despite optimized standard therapy

Mechanism of Action

Safinamide Mesylate works through a dual mechanism:

• It is a selective and reversible monoamine oxidase-B (MAO-B) inhibitor, which increases dopamine levels in the brain by preventing its breakdown.
• It also modulates abnormal glutamate release, which may help reduce excitotoxicity and improve motor function.

Through these combined actions, Safina Tablet helps restore dopamine balance in the central nervous system, improving movement and reducing Parkinsonian symptoms.

Dosage & Administration

• The recommended dose should be determined by a physician based on patient response and concurrent levodopa therapy.
• Usually taken once daily at the same time each day.
• Can be taken with or without food.
• Dosage adjustments may be required in patients with liver impairment.
• It is important to continue other Parkinson’s medications as prescribed unless advised otherwise by a healthcare professional.

Precautions

• Use with caution in patients with liver disease
• Not recommended in severe hepatic impairment
• Monitor for symptoms of serotonin syndrome when used with certain antidepressants
• May cause sudden changes in blood pressure or dyskinesia when combined with levodopa
• Patients should avoid abrupt discontinuation without medical advice
• Caution is advised in patients with a history of psychosis or impulse control disorders

Side Effects

Common and potential side effects include:

• Dyskinesia (involuntary movements)
• Nausea
• Insomnia or sleep disturbances
• Dizziness
• Headache
• Orthostatic hypotension (drop in blood pressure on standing)
• Hallucinations or confusion in susceptible patients

Seek immediate medical attention if severe psychiatric symptoms, high fever, or unusual muscle stiffness occurs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Safina Tablet may interact with:

• Antidepressants (SSRIs, SNRIs, TCAs)
• Other MAO inhibitors
• Opioid medications such as tramadol or pethidine
• Dopaminergic agents used in Parkinson’s disease

A complete medication review is essential before starting therapy.

Storage

• Store below 30°C in a dry place
• Protect from moisture and direct sunlight
• Keep out of reach of children.