Azomid Suspension 1% contains Brinzolamide, a topical ophthalmic carbonic anhydrase inhibitor used to reduce elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. By effectively lowering intraocular pressure, Azomid Suspension 1% helps prevent progressive optic nerve damage and visual field loss, which are major risks associated with untreated glaucoma.

This sterile ophthalmic suspension is designed for local use in the eye and provides targeted action with minimal systemic absorption, making it suitable for long-term management of eye pressure-related disorders.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Brinzolamide 1% w/v

Therapeutic Class

Carbonic anhydrase inhibitor (ophthalmic)

Indications

Azomid Suspension 1% is indicated for:

• Open-angle glaucoma

• Ocular hypertension

• Reduction of elevated intraocular pressure

• Use as monotherapy or as adjunctive therapy with other intraocular pressure–lowering agents such as beta-blockers

Pharmacology

Brinzolamide is a highly specific inhibitor of carbonic anhydrase II, an enzyme found in the ciliary processes of the eye. Carbonic anhydrase plays a key role in the formation of aqueous humor. Inhibition of this enzyme leads to decreased bicarbonate ion formation, resulting in reduced sodium and fluid transport. This ultimately lowers aqueous humor secretion and reduces intraocular pressure.

After topical ocular administration, Brinzolamide accumulates in red blood cells due to its affinity for carbonic anhydrase. Systemic exposure is minimal, and its action remains largely localized to ocular tissues, contributing to its favorable safety profile during long-term use.

Dosage and Administration

Azomid Suspension 1% is intended for ophthalmic use only.

• Adults and elderly: One drop in the affected eye(s) two to three times daily, or as directed by a physician

Before use, the bottle should be shaken well to ensure uniform suspension. If more than one ophthalmic product is being used, an interval of at least 5–10 minutes should be allowed between applications.

Contraindications

Azomid Suspension 1% is contraindicated in patients with:

• Known hypersensitivity to Brinzolamide or any component of the formulation

• Severe renal impairment

Side Effects

Commonly reported side effects include:

• Blurred vision (temporary)

• Eye discomfort or irritation

• Bitter or unusual taste

• Dry eyes

• Conjunctival hyperemia

Less common reactions may include headache, nausea, or eye discharge. Most adverse effects are mild and transient.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

Caution should be exercised in patients with:

• Renal or hepatic impairment

• Corneal endothelial disorders

• History of sulfonamide hypersensitivity

The suspension may cause temporary blurred vision; patients should avoid driving or operating machinery until vision is clear. Contact lenses should be removed prior to instillation and may be reinserted after at least 15 minutes.

Pregnancy and Lactation

Azomid Suspension 1% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised during lactation, and use should be based on medical judgment considering maternal need.

Storage Conditions

Store below 30°C. Protect from light. Do not freeze. Keep the bottle tightly closed and out of reach of children.

Mode of Action

Brinzolamide reduces intraocular pressure by inhibiting carbonic anhydrase II in the eye, leading to decreased aqueous humor production. This action helps maintain normal eye pressure and reduces the risk of glaucoma-related optic nerve damage.