Denbac Capsule 50 mg contains Dantrolene Sodium, a skeletal muscle relaxant used in the management of conditions associated with severe muscle spasticity and in the treatment of malignant hyperthermia. It works by acting directly on skeletal muscle fibers, helping to reduce excessive muscle contraction and rigidity.

This medicine is particularly valuable in hospital settings and neuromuscular conditions where control of abnormal muscle activity is required.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each capsule contains:

• Dantrolene Sodium 50 mg

Mechanism of Action

Dantrolene Sodium acts directly on skeletal muscle by inhibiting calcium release from the sarcoplasmic reticulum through ryanodine receptors (RyR1). By reducing intracellular calcium levels, it decreases muscle contraction strength and relieves spasticity. In malignant hyperthermia, it helps reverse uncontrolled calcium release that leads to life-threatening muscle rigidity and hypermetabolism.

Indications

Denbac Capsule 50 mg is indicated for:

• Chronic spasticity due to neurological disorders (e.g., cerebral palsy, spinal cord injury, multiple sclerosis)
• Malignant hyperthermia (treatment and prevention during anesthesia)
• Severe muscle rigidity and spasm conditions
• Post-stroke spasticity (as prescribed by a physician)

Dosage and Administration

• To be taken orally as directed by a physician
• Dosage is gradually increased based on patient response and tolerance
• For malignant hyperthermia, dosing is managed in a hospital emergency setting
• Should be swallowed whole with water
• Regular monitoring of liver function is recommended during long-term use

Contraindications

Denbac Capsule should not be used in:

• Known hypersensitivity to Dantrolene Sodium
• Active liver disease or significant hepatic impairment
• Patients requiring full muscle tone for functional movement without medical supervision

Side Effects

Possible side effects include:

• Drowsiness or dizziness
• Muscle weakness
• Fatigue
• Diarrhea
• Nausea or vomiting
• Hepatotoxicity (risk increases with long-term use)
• Rare allergic skin reactions

Precautions

• Liver function tests should be monitored regularly during therapy
• Use cautiously in elderly or debilitated patients
• May cause muscle weakness affecting daily activities
• Avoid alcohol due to increased CNS depression
• Patients should be monitored for signs of liver toxicity

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Denbac Capsule may interact with:

• CNS depressants (increased sedation)
• Other muscle relaxants (additive effects)
• Hepatotoxic drugs (increased risk of liver damage)
• Calcium channel blockers (may potentiate muscle effects in certain cases)

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.