Telisa-A Tablet 5 mg+40 mg is a combination antihypertensive medication containing Amlodipine Besilate 5 mg, a calcium channel blocker (CCB), and Telmisartan 40 mg, an angiotensin II receptor blocker (ARB). This formulation is specifically designed for enhanced blood pressure control in adults who require a dual mechanism to achieve optimal cardiovascular protection.

Amlodipine works by relaxing blood vessels and reducing the resistance against which the heart pumps, while Telmisartan blocks angiotensin II, a hormone that constricts blood vessels and increases blood pressure. The combination provides synergistic blood pressure reduction, improves arterial flexibility, and offers protection for the heart and kidneys. The once-daily oral dosage ensures convenience and adherence for long-term therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Telisa-A Tablet 5 mg+40 mg is indicated for:

• Essential hypertension in adults, particularly when monotherapy with either Amlodipine or Telmisartan is insufficient

• Combination therapy for patients requiring dual-action blood pressure control

• Cardiovascular risk reduction, including prevention of stroke, myocardial infarction, and other vascular events in hypertensive patients

• Patients who need long-term management of hypertension with minimal fluctuations in blood pressure

It is intended for ongoing control of blood pressure and cardiovascular protection, not for immediate relief of hypertensive crises.

Mechanism of Action

Telisa-A combines two complementary antihypertensive mechanisms:

• Amlodipine Besilate (Calcium Channel Blocker): Inhibits calcium influx in vascular smooth muscle, leading to vasodilation and reduced peripheral resistance, which lowers blood pressure

• Telmisartan (ARB): Blocks angiotensin II from binding to AT1 receptors, preventing vasoconstriction and reducing aldosterone-mediated sodium and water retention

• Synergistic effect: Dual mechanism results in more consistent and potent blood pressure control compared to monotherapy, while also providing cardiovascular and renal protection

This combination addresses multiple pathways in the renin-angiotensin-aldosterone system (RAAS) and vascular resistance, improving overall blood pressure management.

Dosage and Administration

• The usual adult dose is one tablet orally once daily, with or without food

• Tablets should be swallowed whole with water

• Dose adjustments may be necessary in patients with renal or hepatic impairment

• Consistent daily use is essential for maintaining target blood pressure and preventing cardiovascular complications

• Periodic monitoring of blood pressure, kidney function, and electrolytes (especially potassium) is recommended

Precautions and Warnings

• Pregnancy: Avoid use during the second and third trimesters due to potential fetal harm

• Use cautiously in patients with severe liver or kidney impairment

• May cause dizziness, lightheadedness, or swelling, especially during initiation of therapy

• Hydrochlorothiazide may increase photosensitivity; avoid excessive sunlight or use protective clothing if exposed

• Inform your healthcare provider about all medications, including diuretics, NSAIDs, or other antihypertensives, to prevent interactions

Side Effects

Telisa-A Tablet 5 mg+40 mg is generally well tolerated. Common side effects include:

• Dizziness, headache, or fatigue

• Mild swelling of the ankles or feet (peripheral edema)

• Gastrointestinal discomfort such as nausea

• Rarely, hypotension or electrolyte imbalances

• Very rare: allergic reactions, kidney function changes, or severe cardiovascular events

Seek immediate medical attention if severe dizziness, shortness of breath, swelling, or unusual symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Telisa-A Tablet 5 mg+40 mg provides effective once-daily blood pressure control with dual mechanisms, offering potent cardiovascular and renal protective benefits for patients requiring combination therapy.