Insul Injection 50% + 50% (100 IU/ml) is a premixed human insulin formulation containing Regular Human Insulin (50%) and Isophane Insulin Human (NPH, 50%). It is used for the effective management of diabetes mellitus by providing both rapid and intermediate blood glucose control in a single injection. This balanced combination helps maintain stable glycemic levels throughout the day.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Regular Insulin Human 50% (short-acting)
• Isophane Insulin Human (NPH) 50% (intermediate-acting)
• Strength: 100 IU/ml

Mechanism of Action

• Regular Insulin: Rapidly lowers post-meal blood glucose by facilitating cellular uptake of glucose and promoting its utilization.
• Isophane Insulin (NPH): Provides a slower, sustained release of insulin, maintaining basal glucose control between meals and overnight.

Together, this 50:50 combination delivers a more balanced insulin action profile suitable for patients requiring equal prandial and basal insulin coverage.

Indications

Insul Injection is indicated for:

• Type 1 diabetes mellitus
• Type 2 diabetes mellitus not controlled with oral antidiabetic drugs
• Gestational diabetes requiring insulin therapy
• Hospitalized patients with hyperglycemia
• Patients requiring premixed insulin for simplified dosing regimens

Dosage and Administration

• Administered via subcutaneous injection only
• Dosage is individualized based on blood glucose monitoring, diet, and physician guidance
• Commonly injected 30–45 minutes before meals
• Injection sites include abdomen, thigh, or upper arm
• Rotate injection sites to prevent lipodystrophy

Possible Side Effects

Common side effects include:

• Hypoglycemia (most important and common risk)
• Weight gain
• Injection site reactions (redness, swelling, or itching)
• Lipodystrophy (fat changes at injection site)

Less common but serious effects:

• Severe hypoglycemia leading to confusion, seizures, or loss of consciousness
• Allergic reactions
• Hypokalemia (low potassium levels)

Precautions

• Regular blood glucose monitoring is essential
• Do not skip meals after insulin injection
• Alcohol may increase risk of hypoglycemia
• Dose adjustments may be needed during illness, stress, or changes in diet
• Use cautiously in patients with kidney or liver impairment

Contraindications

• Hypoglycemia episodes
• Known hypersensitivity to human insulin or any component of the product

Drug Interactions

• Corticosteroids may increase blood glucose levels
• Beta-blockers may mask symptoms of hypoglycemia
• Oral antidiabetic drugs may enhance insulin effect
• Thyroid hormones and diuretics may alter glucose control

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a refrigerator at 2°C to 8°C
• Do not freeze
• Protect from heat and direct sunlight
• Once opened, may be kept at room temperature for a limited period as advised

Important Notes

Insul Injection 50% + 50% (100 IU/ml) provides a balanced premixed insulin option for patients requiring equal basal and prandial glucose control. Proper adherence to diet, injection timing, and regular monitoring is essential for safe and effective diabetes management.