Janmet Tablet 50 mg + 1000 mg is a combination oral antidiabetic medication containing Sitagliptin 50 mg and Metformin Hydrochloride 1000 mg. It is indicated for the treatment of Type 2 Diabetes Mellitus in adults who require improved glycemic control beyond diet, exercise, or monotherapy. This higher-strength Metformin formulation is particularly beneficial for patients who need intensified blood glucose management.

Type 2 diabetes is characterized by insulin resistance, impaired insulin secretion, and excessive glucose production by the liver. If not properly controlled, elevated blood sugar levels can lead to serious long-term complications such as cardiovascular disease, kidney damage, neuropathy, and retinopathy. Janmet 50/1000 mg provides a dual mechanism of action that targets multiple underlying defects in diabetes, helping patients maintain stable blood glucose levels and reduce complication risks.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Sitagliptin 50 mg (as Sitagliptin Phosphate)

• Metformin Hydrochloride 1000 mg

Mechanism of Action

Janmet works through complementary actions of its two active components:

Sitagliptin is a DPP-4 inhibitor. It increases the levels of incretin hormones (GLP-1 and GIP), which enhance glucose-dependent insulin secretion and suppress glucagon release. This helps reduce postprandial (after-meal) blood glucose levels without causing excessive hypoglycemia.

Metformin reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity in muscle and peripheral tissues. It primarily lowers fasting blood glucose and enhances overall glycemic control.

Together, these agents provide comprehensive management of both fasting and post-meal blood sugar levels.

Indications

Janmet Tablet 50 mg + 1000 mg is indicated for:

• Treatment of Type 2 Diabetes Mellitus in adults

• Patients inadequately controlled on Metformin alone

• Patients already taking Sitagliptin and Metformin separately

• Combination therapy with other antidiabetic medications when required

It is not recommended for Type 1 diabetes or diabetic ketoacidosis.

Dosage and Administration

The dosage should be individualized based on the patient’s clinical condition and response to therapy. It is usually taken once or twice daily with meals to minimize gastrointestinal side effects associated with Metformin. Tablets should be swallowed whole with water and not crushed or chewed.

Regular monitoring of blood glucose and HbA1c levels is essential to evaluate treatment effectiveness.

Benefits

• Effective control of both fasting and postprandial glucose

• Higher Metformin strength for patients needing intensified therapy

• Low risk of hypoglycemia when used alone

• Convenient fixed-dose combination

• Supports long-term reduction of diabetes-related complications

Precautions

• Use cautiously in patients with renal or hepatic impairment

• Assess kidney function before and during treatment

• Risk of rare but serious lactic acidosis with Metformin

• Inform healthcare provider about all other medications

• Use during pregnancy or breastfeeding only if prescribed

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Nausea, diarrhea, abdominal discomfort

• Headache

• Upper respiratory tract symptoms

• Hypoglycemia (more likely when combined with insulin or sulfonylureas)

Seek immediate medical attention if symptoms such as severe weakness, muscle pain, breathing difficulty, or allergic reactions occur.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.