Kilbac 750 mg/vial is a broad-spectrum injectable antibiotic containing Cefuroxime, a second-generation cephalosporin. It is widely used for the treatment of a variety of mild to severe infections caused by susceptible bacteria, including β-lactamase–producing strains. Kilbac is suitable for both adult and pediatric patients and can be administered via intramuscular (IM) or intravenous (IV) routes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Second Generation Cephalosporins

Indications

Kilbac 750 mg/vial is indicated for the treatment of infections caused by sensitive organisms, including:

• Ear, Nose, and Throat Infections

  • Pharyngitis and tonsillitis caused by Streptococcus pyogenes

  • Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (β-lactamase producing strains), or Streptococcus pyogenes

  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae

• Lower Respiratory Tract Infections

  • Pneumonia

  • Acute bacterial exacerbation of chronic bronchitis

  • Secondary bacterial infections of acute bronchitis

• Skin and Soft Tissue Infections

  • Caused by Staphylococcus aureus (including β-lactamase producing strains) or Streptococcus pyogenes

• Urinary Tract Infections

  • Caused by Escherichia coli or Klebsiella pneumoniae

• Bone and Joint Infections

  • Caused by Staphylococcus aureus

• Sexually Transmitted Infections

  • Gonorrhoea caused by penicillinase-producing and non-producing strains of Neisseria gonorrhoeae

• Other Infections

  • Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

  • Surgical prophylaxis

  • Meningitis

  • Multidrug-resistant typhoid fever

Pharmacology

Cefuroxime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis. It has strong stability against bacterial β-lactamase enzymes, making it effective against many strains resistant to ampicillin and amoxicillin. Its broad antimicrobial spectrum covers both Gram-positive and Gram-negative organisms.

Dosage and Administration

Parenteral Use

• Adults

  • Standard dose: 750 mg IM or IV three times daily

  • Severe infections: Up to 1.5 g IV three times daily

  • Meningitis: 3 g IV three times daily

  • Gonorrhoea: 1.5 g IM as a single dose

  • Surgical prophylaxis: 1.5 g IV at induction of anesthesia

• Children (above 3 months)

  • 30–100 mg/kg/day in 3–4 divided doses

  • Meningitis: 200–240 mg/kg/day initially

• Neonates

  • 30–100 mg/kg/day in 2–3 divided doses

Dosage and duration depend on the severity and type of infection and should be determined by a physician.

Reconstitution

• 750 mg IM: Add 3 ml water for injection

• 750 mg IV: Add 8 ml water for injection

• 1.5 g IV: Add 16 ml water for injection

The reconstituted solution should be administered slowly over 3–5 minutes. Freshly prepared solutions are recommended.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

No clinically significant or potentially hazardous drug interactions have been reported.

Contraindications

Kilbac is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics.

Side Effects

Cefuroxime is generally well tolerated. Possible side effects include:

• Skin rash

• Gastrointestinal disturbances such as diarrhea or nausea

• Overgrowth of non-susceptible organisms with prolonged use

Most adverse effects are mild and transient.

Use in Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. The drug is excreted in human breast milk; therefore, caution is advised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients receiving potent diuretics

• Caution in patients with a history of colitis

• Cross-reactivity may occur in penicillin-allergic patients, though it is uncommon

Storage Conditions

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Mode of Action

Cefuroxime exerts its antibacterial effect by inhibiting the synthesis of the bacterial cell wall, leading to cell lysis and death. Its resistance to β-lactamase enzymes enhances its effectiveness against resistant bacterial strains.