Klarix 70 ml is an oral antibiotic suspension containing Clarithromycin, a macrolide antibiotic with broad-spectrum activity. It is commonly prescribed for respiratory tract infections, skin and soft tissue infections, and as part of combination therapy for the eradication of Helicobacter pylori in patients with duodenal ulcers. Klarix 70 ml is suitable for both adult and pediatric patients and is well tolerated due to its improved acid stability compared to erythromycin.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Macrolides

Indications

Klarix 70 ml is indicated for the treatment of the following infections caused by susceptible organisms:

• Streptococcal pharyngitis and tonsillitis

• Acute and chronic sinusitis

• Infective exacerbations of chronic bronchitis

• Community-acquired pneumonia

• Atypical pneumonia

• Skin and soft tissue infections

• Adjunctive therapy in the eradication of Helicobacter pylori in patients with duodenal ulcers

Pharmacology

Clarithromycin acts by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, blocking translocation and thereby preventing bacterial growth. Klarix 70 ml is active against most Gram-positive organisms, Chlamydia, Mycoplasma, and some Gram-negative bacteria. It demonstrates equal or greater in vitro activity compared to erythromycin and is more acid-stable, resulting in improved gastrointestinal tolerability. Clarithromycin also shows enhanced activity against Haemophilus influenzae.

Dosage and Administration

Adults:

• Pharyngitis/Tonsillitis: 250 mg every 12 hours for 10 days

• Acute maxillary sinusitis: 500 mg every 12 hours for 14 days

• Chronic bronchitis: 250–500 mg every 12 hours for 7–14 days

• Pneumonia: 250 mg every 12 hours for 7–14 days

• Uncomplicated skin and skin structure infections: 250 mg every 12 hours for 7–14 days

• Community-acquired upper and lower respiratory tract infections: 250–500 mg every 12 hours for 5–14 days

Children:

• Body weight under 8 kg: 7.5 mg/kg twice daily

• 8–11 kg (1–2 years): 2.5 ml twice daily

• 12–19 kg (3–6 years): 5 ml twice daily

• 20–29 kg (7–9 years): 7.5 ml twice daily

• 30–40 kg (10–12 years): 10 ml twice daily

Dosage and duration should be determined by the physician based on infection severity and patient response.

Administration

Klarix 70 ml may be administered with or without food.

Drug Interactions

• Theophylline: Concurrent use may increase serum theophylline concentrations

• Terfenadine: Clarithromycin may alter the metabolism of terfenadine, increasing the risk of cardiac adverse effects

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to clarithromycin, erythromycin, or other macrolide antibiotics

• Patients receiving terfenadine with pre-existing cardiac abnormalities or electrolyte disturbances

Side Effects

Klarix 70 ml is generally well tolerated. Possible side effects include:

• Nausea, vomiting, diarrhoea, and abdominal pain

• Stomatitis and glossitis

• Headache and taste disturbance

• Allergic reactions ranging from mild skin reactions to anaphylaxis

• Rare transient central nervous system effects such as dizziness, insomnia, anxiety, or hallucinations

Use in Pregnancy and Lactation

Klarix 70 ml is not recommended during pregnancy due to limited clinical experience. Breastfeeding should be discontinued during treatment, as clarithromycin is excreted in breast milk.

Precautions and Warnings

• Use with caution in patients with hepatic or renal impairment

• Prolonged or repeated use may result in overgrowth of non-susceptible bacteria or fungi

• Discontinue treatment and initiate appropriate therapy if superinfection occurs

Overdose

Ingestion of large amounts may cause gastrointestinal symptoms. Rare cases of altered mental status and electrolyte disturbances have been reported. Management includes supportive care and elimination of unabsorbed drug. Haemodialysis and peritoneal dialysis are not effective in significantly reducing serum clarithromycin levels.

Storage Conditions

Store in a cool, dry place away from light and moisture. After reconstitution, use within 7 days at room temperature or within 14 days if refrigerated. Keep out of reach of children.

Use in Special Populations

Klarix 70 ml may be used in neonates and children at appropriate, physician-recommended doses.

Duration of Treatment

• Adults and children over 12 years: Usually 6–14 days

• H. pylori eradication in duodenal ulcer patients: 6–14 days as part of combination therapy

Reconstitution

Add 45 ml of water to the granules in the bottle and shake well to obtain 70 ml of reconstituted suspension. Each 5 ml of suspension contains 125 mg of clarithromycin.

Mode of Action

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, leading to suppression of bacterial growth and replication.