Leo Tablet 750 mg contains Levofloxacin Hemihydrate, a broad-spectrum fluoroquinolone antibiotic used to treat serious bacterial infections in adults. It is highly effective against Gram-positive and Gram-negative bacteria, including atypical pathogens, and is commonly prescribed for severe respiratory tract infections, complicated urinary tract infections, skin and soft tissue infections, and certain gastrointestinal infections.

Levofloxacin works as a bactericidal agent, killing bacteria by inhibiting enzymes essential for bacterial DNA replication, transcription, and repair, ensuring rapid resolution of infection. The 750 mg formulation is particularly suited for serious infections or infections caused by resistant bacteria, providing a higher, effective systemic dose.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Levofloxacin Hemihydrate 750 mg

Mechanism of Action

Levofloxacin belongs to the fluoroquinolone class and works by:

• Inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for DNA replication and repair

• Disrupting bacterial protein synthesis and replication

• Causing bacterial cell death, leading to rapid resolution of infection

This mechanism ensures broad-spectrum bactericidal activity against common pathogens such as Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Mycoplasma pneumoniae, and Chlamydophila pneumoniae. Its unique mode of action also helps in minimizing cross-resistance with other antibiotic classes.

Indications

Leo Tablet 750 mg is indicated for:

• Severe respiratory tract infections, including community-acquired pneumonia, acute bacterial sinusitis, and exacerbations of chronic bronchitis

• Complicated urinary tract infections and pyelonephritis

• Skin and soft tissue infections caused by susceptible bacteria

• Complicated gastrointestinal infections, such as infections caused by Salmonella or Shigella species

• Cases where lower-dose antibiotics are insufficient or resistance is suspected

Dosage and Administration

• Adults: 750 mg orally once daily, or as prescribed by the physician based on infection severity

• Tablets should be taken with or without food, swallowed whole with a full glass of water

• Maintain adequate hydration during therapy to support kidney function

• Complete the entire prescribed course, even if symptoms improve early, to prevent recurrence and antibiotic resistance

• Dose adjustment is required in patients with renal impairment

Benefits

• Broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria

• Rapid bactericidal activity for quick symptom relief

• Convenient once-daily oral dosing for outpatient therapy

• Suitable for serious or complicated infections where higher systemic exposure is needed

• Reduces risk of infection progression and complications

Precautions

• Use cautiously in patients with kidney or liver disease

• Avoid excessive sun exposure, as fluoroquinolones may cause photosensitivity

• Not recommended for children, pregnant, or breastfeeding women unless prescribed

• Inform your doctor about other medications, particularly antacids, iron supplements, or multivitamins, which may interfere with absorption

• Monitor for tendon pain or swelling, as fluoroquinolones can rarely cause tendonitis or tendon rupture, especially in elderly patients

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Nausea, vomiting, diarrhea

• Headache or dizziness

• Abdominal discomfort

• Mild fatigue

Rare but serious side effects:

• Tendon rupture or tendinitis

• Peripheral neuropathy (numbness or tingling)

• Severe allergic reactions

• Heart rhythm abnormalities (QT prolongation)

Seek immediate medical attention if severe symptoms, tendon pain, or neurological signs occur.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.