Leukin Tablet 50 mg contains Mercaptopurine, an antimetabolite and immunosuppressive medicine used in the treatment of certain cancers and autoimmune conditions. It is most commonly used in acute lymphoblastic leukemia (ALL) as part of combination chemotherapy regimens. It works by slowing or stopping the growth of cancer cells and abnormal immune cells in the body.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Mercaptopurine 50 mg

Mechanism of Action

Mercaptopurine is a purine analog that interferes with DNA and RNA synthesis. It is converted inside the body into active metabolites that inhibit purine nucleotide formation, which is essential for rapidly dividing cells. This results in suppression of cancer cell proliferation and modulation of overactive immune responses.

Indications

Leukin Tablet 50 mg is indicated for:

• Acute lymphoblastic leukemia (ALL)
• Maintenance therapy in leukemia treatment protocols
• Certain autoimmune disorders (off-label use under specialist supervision)
• Inflammatory bowel disease (in selected cases)

Dosage and Administration

• Dosage is strictly individualized based on body weight, disease type, and blood counts
• Usually taken once daily or as directed by the oncologist
• Should be taken on an empty stomach for better absorption
• Regular blood tests are required during therapy
• Do not change dose without medical advice

Benefits

• Effective in long-term maintenance therapy of leukemia
• Helps prevent relapse of acute lymphoblastic leukemia
• Suppresses abnormal immune cell activity
• Can be used in combination with other chemotherapy agents
• Well-established and widely used in oncology protocols

Side Effects

Common side effects may include:

• Nausea and vomiting
• Loss of appetite
• Fatigue
• Mouth ulcers
• Temporary hair thinning

Serious side effects may include:

• Bone marrow suppression (low blood counts)
• Liver toxicity
• Increased risk of infections
• Pancreatitis (rare)

Immediate medical attention is required if severe symptoms occur.

Precautions and Warnings

• Regular monitoring of complete blood count (CBC) and liver function is essential
• Use cautiously in patients with liver disease or low blood counts
• Increased risk of infections due to immune suppression
• Avoid use during pregnancy unless clearly advised by a specialist
• Dose adjustment may be required in patients with TPMT enzyme deficiency

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Leukin Tablet may interact with:

• Allopurinol (requires dose reduction of Mercaptopurine)
• Other chemotherapy agents
• Immunosuppressive drugs
• Vaccines (especially live vaccines)

Always inform your doctor about all medications being used.

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.