Limaryl M Tablet contains a combination of Glimepiride and Metformin, two widely used oral antidiabetic agents. This dual-action formulation is designed for the management of type 2 diabetes mellitus when blood glucose levels are not adequately controlled with single-drug therapy.

It works through complementary mechanisms to improve insulin secretion and reduce glucose production in the body, providing more effective glycemic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredients: Glimepiride + Metformin Hydrochloride
• Strength: 2 mg + 500 mg
• Dosage Form: Oral tablet

Mechanism of Action

This combination works through two different but complementary pathways:

Glimepiride:

• Stimulates insulin release from pancreatic beta cells
• Improves peripheral glucose uptake

Metformin:

• Reduces hepatic glucose production
• Improves insulin sensitivity
• Decreases intestinal absorption of glucose

Together, they help achieve better and more stable blood sugar control.

Indications

Limaryl M Tablet is indicated for:

• Type 2 diabetes mellitus
• Patients inadequately controlled with diet and exercise alone
• Patients not responding sufficiently to monotherapy with Glimepiride or Metformin
• Combination therapy for improved glycemic control

Dosage and Administration

• Dosage is individualized based on blood glucose levels and physician guidance
• Usually taken once or twice daily with meals
• Swallow whole with water
• Do not skip meals to reduce risk of hypoglycemia
• Regular blood glucose monitoring is recommended

Benefits

• Dual mechanism for better blood sugar control
• Helps reduce fasting and post-meal glucose levels
• Improves insulin sensitivity and secretion
• Convenient fixed-dose combination
• Reduces pill burden compared to separate tablets
• Supports long-term diabetes management

Side Effects

Common side effects may include:

• Hypoglycemia (low blood sugar)
• Nausea or vomiting
• Abdominal discomfort
• Diarrhea
• Metallic taste (due to Metformin)
• Headache

Less common but serious effects:

• Lactic acidosis (rare, associated with Metformin)
• Weight gain (due to Glimepiride)
• Allergic skin reactions
• Liver enzyme abnormalities

Precautions and Warnings

• Use only under strict medical supervision
• Risk of hypoglycemia, especially if meals are missed
• Avoid excessive alcohol intake (risk of lactic acidosis)
• Caution in kidney or liver impairment
• Regular monitoring of renal function and blood glucose is required
• Temporary discontinuation may be required before surgery or contrast imaging

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Insulin is preferred; use only if prescribed
• Lactation: Not recommended unless advised by physician
• Pediatrics: Not routinely recommended
• Elderly: Requires careful dose adjustment and monitoring

Storage

• Store below 25°C
• Protect from moisture and light
• Keep in original packaging
• Keep out of reach of children.