Lipril Tablet 10 mg contains Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension, heart failure, and certain conditions following myocardial infarction. By inhibiting the ACE enzyme, Lipril reduces the production of angiotensin II, a hormone that constricts blood vessels and stimulates aldosterone release. This leads to vasodilation, decreased blood pressure, and reduced strain on the heart.

Lipril 10 mg is widely prescribed for managing high blood pressure, either alone or in combination with other antihypertensive medications. It helps prevent complications of hypertension, such as stroke, heart attack, and kidney damage. In patients with heart failure, Lipril improves symptoms, exercise tolerance, and survival by decreasing the workload on the heart.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Angiotensin-Converting Enzyme (ACE) Inhibitor

Indications

Lipril Tablet 10 mg is indicated for:

• Hypertension: to lower blood pressure and reduce the risk of cardiovascular events

• Heart failure: as part of a comprehensive management plan to improve symptoms and survival

• Post-myocardial infarction: to improve survival and reduce complications following a heart attack

• Diabetic nephropathy: to slow the progression of kidney disease in hypertensive diabetic patients

This medication is suitable for adults, and its dose can be adjusted based on clinical response and kidney function.

Pharmacology

Mechanism of Action:

• Lisinopril inhibits the angiotensin-converting enzyme, preventing the conversion of angiotensin I to angiotensin II

• Reduces vasoconstriction and lowers aldosterone secretion, leading to decreased blood volume and blood pressure

• Improves cardiac output in heart failure by reducing afterload and preload

• Has renal protective effects in diabetic patients by reducing intraglomerular pressure

Clinical Benefits:

• Sustained reduction of systolic and diastolic blood pressure

• Improved heart function in congestive heart failure

• Reduced risk of cardiovascular morbidity and mortality

• Slowed progression of renal disease in hypertensive patients

Dosage and Administration

• Adults with hypertension: 10 mg once daily initially, can be increased based on response, up to 40 mg daily in a single or divided dose

• Heart failure: 5–10 mg daily initially, with gradual titration to 20–40 mg daily as tolerated

• Post-myocardial infarction: 5 mg within 24 hours, then titrate as appropriate

• Take with or without food, preferably at the same time each day

• Dose adjustment may be necessary in patients with renal impairment

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Monitor kidney function and serum potassium before and during therapy

• Use with caution in patients with hypotension, aortic stenosis, or bilateral renal artery stenosis

• May cause dizziness; avoid driving or operating machinery until effects are known

• Avoid concomitant use with potassium-sparing diuretics or potassium supplements unless closely monitored

Possible Side Effects

• Common: cough, dizziness, headache, fatigue, hypotension

• Gastrointestinal: nausea, diarrhea

• Rare but serious: angioedema, hyperkalemia, renal dysfunction

• Seek immediate medical attention for swelling of the face, lips, tongue, or difficulty breathing

Contraindications

• History of angioedema related to ACE inhibitors

• Hypersensitivity to Lisinopril or any component of the formulation

• Pregnancy (particularly in the second and third trimesters)

• Severe renal impairment or dialysis

Pregnancy & Lactation

• Pregnancy Category D: Avoid in pregnancy due to risk of fetal harm

• Not recommended during breastfeeding

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.